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Shyni Varghese

Shyni Varghese

Professor of Biomedical Engineering, Mechanical Engineering & Materials Science and Orthopaedics

Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.

A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:

  • Musculoskeletal tissue repair
  • Disease biophysics, and
  • Organ-on-a-chip technology

A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.

Appointments and Affiliations

  • Professor of Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Ph.D. National Chemical Laboratory (India), 2002

Research Interests

Musculoskeletal tissue repair, disease biophysics and organ-on-a-chip technology

Courses Taught

  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study
  • ME 221L: Structure and Properties of Solids

In the News

Representative Publications

  • Zeng, Y; Hoque, J; Varghese, S, Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair., Acta Biomaterialia (2019) [10.1016/j.actbio.2019.01.060] [abs].
  • Hoque, J; Sangaj, N; Varghese, S, Stimuli-Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine., Macromolecular Bioscience, vol 19 no. 1 (2019) [10.1002/mabi.201800259] [abs].
  • Kumar, V; Varghese, S, Ex Vivo Tumor-on-a-Chip Platforms to Study Intercellular Interactions within the Tumor Microenvironment., Advanced Healthcare Materials (2018) [10.1002/adhm.201801198] [abs].
  • Ryu, JH; Lee, GJ; Shih, Y-RV; Kim, T-I; Varghese, S, Phenylboronic acid-polymers for biomedical applications., Current Medicinal Chemistry (2018) [10.2174/0929867325666181008144436] [abs].
  • Seale, N; Ramaswamy, S; Shih, Y-R; Verma, I; Varghese, S, Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes., Transplantation, vol 102 no. 9 (2018), pp. e373-e381 [10.1097/tp.0000000000002330] [abs].