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Tatiana Segura


Professor of Biomedical Engineering

Professor Tatiana Segura received her BS degree in Bioengineering from the University of California Berkeley and her doctorate in Chemical Engineering from Northwestern University. Her graduate work in designing and understanding non-viral gene delivery from hydrogel scaffolds was supervised by Prof. Lonnie Shea. She pursued post-doctoral training at the Swiss Federal Institute of Technology, Lausanne under the guidance of Prof. Jeffrey Hubbell, where her focus was self-assembled polymer systems for gene and drug delivery. Professor Segura's Laboratory studies the use of materials for minimally invasive in situ tissue repair.   On this topic, she has published over 60 peered reviewed publications. She has been recognized with the Outstanding Young Investigator Award from the American Society of Gene and Cell Therapy, the American Heart Association National Scientist Development Grant, and the CAREER award from National Science Foundation.  She was Elected to the College of Fellows at the American Institute for Medical and Biological Engineers (AIMBE) in 2017. She spent the first 11 years of her career at UCLA department of Chemical and Biomolecular Engineering and has recently relocated to Duke University, where she holds appointments in Biomedical Engineering, Neurology and Dermatology. 

Appointments and Affiliations

  • Visiting Professor in the Department of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Ph.D. Northwestern University, 2004

Research Interests

The design of biomaterials to promote endogenous repair and reducing inflammation through the design of the geometry of the material, and delivering genes, proteins and drugs.

In the News

Representative Publications

  • Nih, LR; Moshayedi, P; Llorente, IL; Berg, AR; Cinkornpumin, J; Lowry, WE; Segura, T; Carmichael, ST, Engineered HA hydrogel for stem cell transplantation in the brain: Biocompatibility data using a design of experiment approach, Data in brief, vol 10 (2017), pp. 202-209 [abs].
  • Zhu, X; Gojgini, S; Chen, T-H; Fei, P; Dong, S; Ho, C-M; Segura, T, Directing three-dimensional multicellular morphogenesis by self-organization of vascular mesenchymal cells in hyaluronic acid hydrogels, Journal of biological engineering, vol 11 (2017), pp. 12-12 [abs].
  • Ray, A; Li, S; Segura, T; Ozcan, A, High-throughput quantification of nanoparticle degradation using computational microscopy and its application to drug delivery nanocapsules, ACS Photonics, vol 4 (2017), pp. 1216-1224 [abs].
  • Nih, LR; Sideris, E; Carmichael, ST; Segura, T, Injection of Microporous Annealing Particle (MAP) Hydrogels in the Stroke Cavity Reduces Gliosis and Inflammation and Promotes NPC Migration to the Lesion, Advanced Materials, vol 29 (2017) [abs].
  • Li, S; Nih, LR; Bachman, H; Fei, P; Li, Y; Nam, E; Dimatteo, R; Carmichael, ST; Barker, TH; Segura, T, Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability, Nature materials, vol 16 (2017), pp. 953-953 [abs].