Karl-Dimiter Bissig

Pediatrics, Medical Genetics

Chen Family Associate Professor of Pediatrics

Karl-Dimiter Bissig Profile Photo
Karl-Dimiter Bissig Profile Photo

Research Interests

Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. We use these next generation humanized mouse models to develop new therapeutic approaches, such as metabolic pathway reprogramming - a CRISPR based gene therapy approach.

Bio

Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. We use these next generation humanized mouse models to develop new therapeutic approaches, such as metabolic pathway reprogramming - a CRISPR based gene therapy approach.

Education

  • MD./PhD. Universitat Bern (Switzerland), 2000

Trainings & Certifications

  • Residency, INTERNAL MEDICINE (2001 - 2005) Inselspital (Switzerland)
  • Postdoctoral Fellow (2005 - 2011) Salk Institute for Biological Studies

Positions

  • Chen Family Associate Professor of Pediatrics
  • Associate Professor in Pediatrics
  • Associate Professor of Biomedical Engineering
  • Associate Professor in Pharmacology and Cancer Biology
  • Affiliate of the Duke Regeneration Center
  • Member of the Duke Cancer Institute

Courses Taught

  • PHARM 494: Research Independent Study
  • PHARM 493: Research Independent Study
  • PHARM 394: Research Independent Study
  • BME 791: Graduate Independent Study
  • BME 493: Projects in Biomedical Engineering (GE)

Publications

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