Emma Chory

Education

• Ph.D. Stanford University, 2018

Positions

• Assistant Professor of Biomedical Engineering

Courses Taught

• BME 791: Graduate Independent Study
• BME 706L: Biotech Design II
• BME 590: Special Topics in Biomedical Engineering
• BME 494: Projects in Biomedical Engineering (GE)
• BME 493: Projects in Biomedical Engineering (GE)
• BME 406L: Biotech Design II
• BME 394: Projects in Biomedical Engineering (GE)

Publications

• Gretton D, Wang B, Edison R, Foner L, Berlips J, Vogel T, et al. Random adversarial threshold search enables automated DNA screening. bioRxiv. 2024.
• Buchthal J, Chory E, Hill Z, Zhou Y, Bondage D, DeAmelio S, et al. Heritable Immunization Establishes a New Model for Pathogen Control. bioRxiv. 2024.
• Chory EJ, Wang M, Ceribelli M, Michalowska AM, Golas S, Beck E, et al. High-throughput approaches to uncover synergistic drug combinations in leukemia. SLAS discoveryu202f: advancing life sciences R & D. 2023 Jun;28(4):193u2013201.
• Garzu00f3n-Porras AM, Chory E, Gryder BE. Dynamic Opposition of Histone Modifications. ACS chemical biology. 2023 Apr;18(4):1027u201336.
• Golas S, Chory EJ. Proximity labeling of endogenous protein interactions enabled by directed evolution. Trends in biotechnology. 2023 Mar;41(3):301u20133.
• Buchthal J, Chory E, Hill Z, Dennison C, Tu B, Wierenga R, et al. Low-cost camera-based estrous tracking enables transgenesis inPeromyscus leucopus, the primary reservoir for Lyme disease. bioRxiv. 2023.
• Zhao EM, Mao AS, de Puig H, Zhang K, Tippens ND, Tan X, et al. RNA-responsive elements for eukaryotic translational control. Nature biotechnology. 2022 Apr;40(4):539u201345.
• DeBenedictis EA, Chory EJ, Gretton DW, Wang B, Golas S, Esvelt KM. Systematic molecular evolution enables robust biomolecule discovery. Nature methods. 2022 Jan;19(1):55u201364.
• Chory EJ, Gretton DW, DeBenedictis EA, Esvelt KM. Enabling high-throughput biology with flexible open-source automation. Molecular systems biology. 2021 Mar;17(3):e9942.
• Chory EJ, Kirkland JG, Chang C-Y, Du2019Andrea VD, Gourisankar S, Dykhuizen EC, et al. Chemical Inhibitors of a Selective SWI/SNF Function Synergize with ATR Inhibition in Cancer Cell Killing. ACS chemical biology. 2020 Jun;15(6):1685u201396.
• DeBenedictis EA, Chory EJ, Gretton D, Wang B, Esvelt K. A high-throughput platform for feedback-controlled directed evolution. Cold Spring Harbor Laboratory. 2020.
• Stokes JM, Yang K, Swanson K, Jin W, Cubillos-Ruiz A, Donghia NM, et al. A Deep Learning Approach to Antibiotic Discovery. Cell. 2020 Apr;181(2):475u201383.
• Stokes JM, Yang K, Swanson K, Jin W, Cubillos-Ruiz A, Donghia NM, et al. A Deep Learning Approach to Antibiotic Discovery. Cell. 2020 Feb;180(4):688-702.e13.
• Chory EJ, Calarco JP, Hathaway NA, Bell O, Neel DS, Crabtree GR. Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome. Molecular cell. 2019 Jan;73(1):61-72.e3.
• Stanton BZ, Chory EJ, Crabtree GR. Chemically induced proximity in biology and medicine. Science (New York, NY). 2018 Mar;359(6380):eaao5902.
• Braun SMG, Kirkland JG, Chory EJ, Husmann D, Calarco JP, Crabtree GR. Rapid and reversible epigenome editing by endogenous chromatin regulators. Nature communications. 2017 Sep;8(1):560.
• Kadoch C, Williams RT, Calarco JP, Miller EL, Weber CM, Braun SMG, et al. Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states. Nature genetics. 2017 Feb;49(2):213u201322.
• Yi JS, Federation AJ, Qi J, Dhe-Paganon S, Hadler M, Xu X, et al. Structure-guided DOT1L probe optimization by label-free ligand displacement. ACS chemical biology. 2015 Mar;10(3):667u201374.
• Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, et al. Erratum: Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors (Nature Communications (2012) 3 (1288) DOI: 10.1038/ncomms2304). Nature Communications. 2013 Jun 12;4.
• Vickers DAL, Chory EJ, Harless MC, Murthy SK. p38 signaling and receptor recycling events in a microfluidic endothelial cell adhesion assay. PloS one. 2013 Jan;8(6):e65828.
• Vickers DAL, Chory EJ, Murthy SK. Separation of two phenotypically similar cell types via a single common marker in microfluidic channels. Lab on a chip. 2012 Sep;12(18):3399u2013407.
• Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, et al. Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nature communications. 2012 Jan;3:1288.

In The News

• Genomic Medicine, Beyond CRISPR (Nov 8, 2024 | Pratt School of Engineering)
• Emma Chory Uses Robotics to Speed Up Cellular Evolution (Aug 24, 2023 | Duke Pratt School of Engineering)