David Needham

Thomas Lord Department of Mechanical Engineering and Materials Science

Professor Emeritus in the Thomas Lord Department of Mechanical Engineering and Materials Science

David Needham Profile Photo

Education

B.S. Nottingham Trent University (United Kingdom), 1975
Ph.D. University of Nottingham (United Kingdom), 1981

Positions

Professor Emeritus in the Thomas Lord Department of Mechanical Engineering and Materials Science
Member of the Duke Cancer Institute

Awards, Honors, and Distinctions

Doctor of Science. University of Nottingham. 2015
Honorary Professor. School of Pharmacy, Nottingham University, Nottingham, UK. 2014
Niels Bohr Professorship,. Danish National Research Foundation, Denmark. 2012
Hans Christian Andersen Academy Professor. University Southern Denmark, Odense, Denmark. 2012
Visiting Professor, MEMPHYS/MultiCaps. University of Southern Denmark, Denmark. 2011
VELUX Visiting Professor Program. VELUX Foundation. 2011
Participant: Series of Workshops and Tutorials on u201cCells and Materials at the Interface between Mathematics, Biology and Engineeringu201d. Institute for Pure and Applied Math, UCLA. 2006
Participant, u201cBlue Sky Committeeu201d . Duke University. 2006
National Academy of Sciences Committee on Biomolecular Materials and Processes. Board on Physics and Astronomy National Research Council, the National Academies . 2006
Recipient F.I.R.S.T. Award. National Institutes of Health. 1988
Alfred M. Hunt Faculty Scholarship. Duke University. 1988
NATO/SERC (England) Fellowship. NATO/SERC . 1983
Oppenheimer Research Fellowship. Cambridge University. 1982

Courses Taught

ME 555: Advanced Topics in Mechanical Engineering

Publications

Needham D. Niclosamide: A career builder. Journal of controlled release : official journal of the Controlled Release Society. 2024 May;369:786–856.
Dickinson MS, Kutsch M, Sistemich L, Hernandez D, Piro AS, Needham D, et al. LPS-aggregating proteins GBP1 and GBP2 are each sufficient to enhance caspase-4 activation both in cellulo and in vitro. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2216028120.
Reddy GB, Kerr DL, Spasojevic I, Tovmasyan A, Hsu DS, Brigman BE, et al. Data from Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma. 2023.
Reddy GB, Kerr DL, Spasojevic I, Tovmasyan A, Hsu DS, Brigman BE, et al. Supplementary Data from Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma. 2023.
Reddy GB, Kerr DL, Spasojevic I, Tovmasyan A, Hsu DS, Brigman BE, et al. Supplementary Data from Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma. 2023.
Reddy GB, Kerr DL, Spasojevic I, Tovmasyan A, Hsu DS, Brigman BE, et al. Data from Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma. 2023.
Adekeye AO, Needham D, Rahman R. Low-Density Lipoprotein Pathway Is a Ubiquitous Metabolic Vulnerability in High Grade Glioma Amenable for Nanotherapeutic Delivery. Pharmaceutics. 2023 Feb;15(2):599.
Needham D. Extraction of niclosamide from commercial approved tablets into aqueous buffered solution creates potentially approvable oral and nasal sprays against COVID-19 and other respiratory infections. AAPS open. 2023 Jan;9(1):9.
Needham D. The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections. Pharmaceutical research. 2022 Jan;39(1):115–41.
Dudiak BM, Nguyen TM, Needham D, Outlaw TC, McCafferty DG. Inhibition of the futalosine pathway for menaquinone biosynthesis suppresses Chlamydia trachomatis infection. FEBS letters. 2021 Dec;595(24):2995–3005.
Needham D. The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology Motivates Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Contagious Variants, and Other Respiratory Viral Infections. 2021 Aug 17;
Amer MH, Alvarez-Paino M, McLaren J, Pappalardo F, Trujillo S, Wong JQ, et al. Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering. Biomaterials. 2021 Jan;266:120450.
Reddy GB, Kerr DL, Spasojevic I, Tovmasyan A, Hsu DS, Brigman BE, et al. Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma. Mol Cancer Ther. 2020 Jul;19(7):1448–61.
Needham D. Development of clinically effective formulations for anticancer applications: why it is so difficult? In: Biomaterials for Cancer Therapeutics: Evolution and Innovation. 2020. p. 599–723.
Alvarez-Paino M, Amer MH, Nasir A, Cuzzucoli Crucitti V, Thorpe J, Burroughs L, et al. Polymer Microparticles with Defined Surface Chemistry and Topography Mediate the Formation of Stem Cell Aggregates and Cardiomyocyte Function. ACS applied materials & interfaces. 2019 Sep;11(38):34560–74.
Munk MB, Utoft A, Larsen FH, Needham D, Risbo J. Oleogelating properties of ethylcellulose in oil-in-water emulsions: The impact of emulsification methods studied by ¹³C MAS NMR, surface tension and micropipette manipulation studies. Food Hydrocolloids. 2019 Apr 1;89:700–6.
Needham D, Kinoshita K, Utoft A. Micro-Surface and -Interfacial Tensions Measured Using the Micropipette Technique: Applications in Ultrasound-Microbubbles, Oil-Recovery, Lung-Surfactants, Nanoprecipitation, and Microfluidics. Micromachines. 2019 Feb;10(2):E105.
Pipó-Ollé E, Walke P, Notabi MK, El-Houri RB, Østergaard Andersen M, Needham D, et al. Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells. Journal of visualized experiments : JoVE. 2019 Feb;(144).
Hervella P, Dam JH, Thisgaard H, Baun C, Olsen BB, Høilund-Carlsen PF, et al. Chelation, formulation, encapsulation, retention, and in vivo biodistribution of hydrophobic nanoparticles labelled with ⁵⁷Co-porphyrin: Oleylamine ensures stable chelation of cobalt in nanoparticles that accumulate in tumors. Journal of controlled release : official journal of the Controlled Release Society. 2018 Dec;291:11–25.
Utoft A, Kinoshita K, Bitterfield DL, Needham D. Manipulating Single Microdroplets of NaCl Solutions: Solvent Dissolution, Microcrystallization, and Crystal Morphology. Langmuir : the ACS journal of surfaces and colloids. 2018 Mar;34(12):3626–41.
Kinoshita K, Parra E, Needham D. Adsorption of ionic surfactants at microscopic air-water interfaces using the micropipette interfacial area-expansion method: Measurement of the diffusion coefficient and renormalization of the mean ionic activity for SDS. Journal of colloid and interface science. 2017 Oct;504:765–79.
Parra E, Hervella P, Needham D. Real-Time Visualization of the Precipitation and Phase Behavior of Octaethylporphyrin in Lipid Microparticles. Journal of pharmaceutical sciences. 2017 Apr;106(4):1025–41.
Brousell SC, Longo TA, Fantony JJ, Etienne W, Needham D, Dewhirst MW, et al. MP65-08 HEAT-TARGETED DRUG DELIVERY USING THE COMBAT BRS DEVICE FOR TREATING BLADDER CANCER. In: Journal of Urology. Ovid Technologies (Wolters Kluwer Health); 2017.
Yi J, Knudsen TA, Nielsen A-L, Duelund L, Christensen M, Hervella P, et al. Data for the size of cholesterol-fat micelles as a function of bile salt concentration and the physico-chemical properties of six liquid experimental pine-derived phytosterol formulations in a cholesterol-containing artificial intestine fluid. Data in brief. 2017 Feb;10:478–81.
Kinoshita K, Parra E, Needham D. New sensitive micro-measurements of dynamic surface tension and diffusion coefficients: Validated and tested for the adsorption of 1-Octanol at a microscopic air-water interface and its dissolution into water. Journal of colloid and interface science. 2017 Feb;488:166–79.
Anibal Disalvo E, Simon S. Preface. In: Permeability and Stability of Lipid Bilayers. 2017. p. iii.
Kinoshita K, Parra E, Hussein A, Utoft A, Walke P, de Bruijn R, et al. From single microparticles to microfluidic emulsification: Fundamental properties (solubility, density, phase separation) from micropipette manipulation of solvent, drug and polymer microspheres. Processes. 2016 Dec 1;4(4).
Bitterfield DL, Utoft A, Needham D. An Activity-Based Dissolution Model for Solute-Containing Microdroplets. Langmuir : the ACS journal of surfaces and colloids. 2016 Dec;32(48):12749–59.
Needham D, Arslanagic A, Glud K, Hervella P, Karimi L, Høeilund-Carlsen P-F, et al. Bottom up design of nanoparticles for anti-cancer diapeutics: "put the drug in the cancer's food". Journal of drug targeting. 2016 Nov;24(9):836–56.
Parra E, Kinoshita K, Needham D. Micropipette Technique Study of Natural and Synthetic Lung Surfactants at the Air-Water Interface: Presence of a SP-B Analog Peptide Promotes Membrane Aggregation, Formation of Tightly Stacked Lamellae, and Growth of Myelin Figures. Langmuir : the ACS journal of surfaces and colloids. 2016 Oct;32(41):10570–81.
Yi J, Knudsen TA, Nielsen A-L, Duelund L, Christensen M, Hervella P, et al. Inhibition of cholesterol transport in an intestine cell model by pine-derived phytosterols. Chemistry and physics of lipids. 2016 Oct;200:62–73.
Needham D. Bringing research to clinical application lessons from thermodox(r): A thermal-sensitive liposome for treatment of cancer. In: Drug Delivery: Fundamentals and Applications: Second Edition. 2016. p. 523–85.
Hervella P, Parra E, Needham D. Encapsulation and retention of chelated-copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core formulation. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV. 2016 May;102:64–76.
Aniket, Gaul DA, Bitterfield DL, Su JT, Li VM, Singh I, et al. Enzyme dehydration using Microglassification™ preserves the protein's structure and function. Journal of pharmaceutical sciences. 2015 Feb;104(2):640–51.
Zagar TM, Vujaskovic Z, Formenti S, Rugo H, Muggia F, O’Connor B, et al. Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer. Int J Hyperthermia. 2014 Aug;30(5):285–94.
Bagatolli LA, Needham D. Quantitative optical microscopy and micromanipulation studies on the lipid bilayer membranes of giant unilamellar vesicles. Chemistry and physics of lipids. 2014 Jul;181:99–120.
Aniket, Gaul DA, Rickard DL, Needham D. Microglassification™: a novel technique for protein dehydration. Journal of pharmaceutical sciences. 2014 Mar;103(3):810–20.
Kinoshita K, Glud K, Needham D. New Measurements of Lung Surfactant Interfacial Tension with Micropipette Manipulation Technique. In: Biophysical Journal. Elsevier BV; 2014. p. 518a-518a.
Olsen BB, Thisgaard H, Vogel S, Thomassen M, Kruse TA, Needham D, et al. Novel radioisotope-based nanomedical approaches. European Journal of Nanomedicine. 2013 Dec 1;5(4):181–93.
Needham D, Dewhirst MW. Materials science and engineering of the low temperature sensitive liposome (LTSL): Composition-structure-property relationships that underlie its design and performance. RSC Smart Materials. 2013 Nov 25;1(1):33–79.
Su JT, Needham D. Mass transfer in the dissolution of a multicomponent liquid droplet in an immiscible liquid environment. Langmuir : the ACS journal of surfaces and colloids. 2013 Nov;29(44):13339–45.
Davis RM, Viglianti BL, Yarmolenko P, Park J-Y, Stauffer P, Needham D, et al. A method to convert MRI images of temperature change into images of absolute temperature in solid tumours. Int J Hyperthermia. 2013 Sep;29(6):569–81.
Needham D. Reverse engineering of the low temperature-sensitive liposome (LTSL) for treating cancer. In: Biomaterials for Cancer Therapeutics: Diagnosis, Prevention and Therapy. 2013. p. 270–348.
Needham D, Park J-Y, Wright AM, Tong J. Materials characterization of the low temperature sensitive liposome (LTSL): effects of the lipid composition (lysolipid and DSPE-PEG2000) on the thermal transition and release of doxorubicin. FARADAY DISCUSSIONS. 2013;161:515–34.
Manzoor AA, Lindner LH, Landon CD, Park J-Y, Simnick AJ, Dreher MR, et al. Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors. Cancer Res. 2012 Nov 1;72(21):5566–75.
Gilchrist SE, Rickard DL, Letchford K, Needham D, Burt HM. Phase separation behavior of fusidic acid and rifampicin in PLGA microspheres. Molecular pharmaceutics. 2012 May;9(5):1489–501.
Needham D. Lipid structures: a brief history of multisomes. Nature nanotechnology. 2011 Dec;6(12):761–2.
Grant GA, Wilson C, Salami S, Macaroni P, Li S, Park J-Y, et al. PRECLINICAL USE OF MILD HYPERTHERMIA TO ENHANCE DRUG DELIVERY TO BRAIN TUMORS. NEURO-ONCOLOGY. 2011 Nov 1;13:111–111.
Landon CD, Park J-Y, Needham D, Dewhirst MW. Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer. Open Nanomed J. 2011 Jan 1;3:38–64.
Rickard DL, Duncan PB, Needham D. Hydration potential of lysozyme: protein dehydration using a single microparticle technique. Biophysical journal. 2010 Mar;98(6):1075–84.
Yarmolenko PS, Zhao Y, Landon C, Spasojevic I, Yuan F, Needham D, et al. Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours. Int J Hyperthermia. 2010;26(5):485–98.
Rickard DL, Duncan PB, Needham D. Hydration Potential of Lysozyme: Protein Dehydration Using a Single Microparticle Technique. In: Biophysical Journal. Elsevier BV; 2010. p. 45a-45a.
Su JT, Duncan PB, Momaya A, Jutila A, Needham D. The effect of hydrogen bonding on the diffusion of water in n-alkanes and n-alcohols measured with a novel single microdroplet method. The Journal of chemical physics. 2010 Jan;132(4):044506.
Yang CM, Plackett D, Needham D, Burt HM. PLGA and PHBV Microsphere Formulations and Solid-State Characterization: Possible Implications for Local Delivery of Fusidic Acid for the Treatment and Prevention of Orthopaedic Infections. Pharmaceutical Research. 2009 Jul;26(7):1644–56.
Chen Q, Krol A, Wright A, Needham D, Dewhirst MW, Yuan F. Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome. Int J Hyperthermia. 2008 Sep;24(6):475–82.
Tashjian JA, Dewhirst MW, Needham D, Viglianti BL. Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques. Int J Hyperthermia. 2008 Feb;24(1):79–90.
Montalvo-Ortiz BL, Sosa B, Velez D, Needham D, Griebenow K. Novel encapsulation of partially dehydrated protein microparticles in PLGA microspheres. Journal of Biotechnology. 2007 Sep;131(2):S51–2.
Holden MA, Needham D, Bayley H. Functional bionetworks from nanoliter water droplets. Journal of the American Chemical Society. 2007 Jul;129(27):8650–5.
Simon SI, Nyunt T, Florine-Casteel K, Ritchie K, Ting-Beall HP, Evans E, et al. Dynamics of neutrophil membrane compliance and microstructure probed with a micropipet-based piconewton force transducer. Annals of biomedical engineering. 2007 Apr;35(4):595–604.
Needham D, Zhelev D. Use of Micropipet Manipulation Techniques to Measure the Properties of Giant Lipid Vesicles. In: Giant Vesicles: Perspectives in Supramolecular Chemistry. 2007. p. 102–47.
Needham D, Ponce A. Nanoscale drug delivery vehicles for solid tumors: A new paradigm for localized drug delivery using temperature sensitive liposomes. In: Nanotechnology for Cancer Therapy. 2006. p. 677–719.
Mills JK, Needham D. Temperature-triggered nanotechnology for chemotherapy: Rapid release from lysolipid temperature-sensitive liposomes. 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. 2006 Dec 8;2:5–8.
Wei C, Lyubchenko YL, Ghandehari H, Hanes J, Stebe KJ, Mao H-Q, et al. New technology and clinical applications of nanomedicine: highlights of the second annual meeting of the American Academy of Nanomedicine (Part I). Nanomedicine : nanotechnology, biology, and medicine. 2006 Dec;2(4):253–63.
Needham D, Wright A, Tong J, Dewhirst MW, Ponce A, Yuan F. Mapping engineering onto biology at the nanoscale: nature's encapsulation technologies as bioinspiration for nano-scale anti-tumor drug delivery. In: Nanomedicine: Nanotechnology, Biology and Medicine. Elsevier BV; 2006. p. 292–3.
Hauck ML, LaRue SM, Petros WP, Poulson JM, Yu D, Spasojevic I, et al. Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors. Clin Cancer Res. 2006 Jul 1;12(13):4004–10.
Ponce AM, Vujaskovic Z, Yuan F, Needham D, Dewhirst MW. Hyperthermia mediated liposomal drug delivery. Int J Hyperthermia. 2006 May;22(3):205–13.
Duncan PB, Needham D. Microdroplet dissolution into a second-phase solvent using a micropipet technique: test of the Epstein-Plesset model for an aniline-water system. Langmuir : the ACS journal of surfaces and colloids. 2006 Apr;22(9):4190–7.
Ponce A, Wright A, Dewhirst M, Needham D. Targeted bioavailability of drugs by triggered release from liposomes. Future Lipidology. 2006 Feb 1;1(1):25–34.
Eichenbaum KD, Thomas AA, Eichenbaum GM, Gibney BR, Needham D, Kiser PF. Oligo-α-hydroxy ester cross-linkers: Impact of cross-linker structure on biodegradable hydrogel networks. Macromolecules. 2005 Dec 27;38(26):10757–62.
Mills JK, Needham D. Lysolipid incorporation in dipalmitoylphosphatidylcholine bilayer membranes enhances the ion permeability and drug release rates at the membrane phase transition. Biochimica et biophysica acta. 2005 Oct;1716(2):77–96.
Lee SH, Needham D, Duncan PB, Jutila A. Water micro-droplets in simple hydrocarbons: Dissolution, free energies of adhesion and bilayer permeability. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 2005. p. U667–U667.
Needham DJ, Leach JA, Merkin JH. The effects of a complexation reaction on travelling wave-fronts in a quadratic autocatalytic system. Q J Mech Appl Math (UK). 2005;58:577–99.
Merkin JH, Needham DJ, Sleeman BD. A mathematical model for the spread of morphogens with density dependent chemosensitivity. Nonlinearity (UK). 2005;18(6):2745–73.
Dhawan M, Price D, Trump D, Kanter P, Shore N, Needham D, et al. New drug delivery approach for the treatment of prostate cancer (preclinical results and phase I study results). In: JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY; 2004. p. 421S-421S.
Dhawan M, Price D, Trump D, Kanter P, Shore N, Needham D, et al. New drug delivery approach for the treatment of prostate cancer (preclinical results and phase I study results). Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2004 Jul;22(14_suppl):4661.
Duncan PB, Needham D. Test of the Epstein-Plesset model for gas microparticle dissolution in aqueous media: effect of surface tension and gas undersaturation in solution. Langmuir : the ACS journal of surfaces and colloids. 2004 Mar;20(7):2567–78.
Mills JK, Needham D. The materials engineering of temperature-sensitive liposomes. Methods in enzymology. 2004 Jan;387:82–113.
Kim DH, Costello MJ, Duncan PB, Needham D. Mechanical properties and microstructure of polycrystalline phospholipid monolayer shells: Novel solid microparticles. Langmuir. 2003 Sep 30;19(20):8455–66.
Ickenstein LM, Arfvidsson MC, Needham D, Mayer LD, Edwards K. Disc formation in cholesterol-free liposomes during phase transition. Biochimica et biophysica acta. 2003 Aug;1614(2):135–8.
Needham D. From properties to performance: The mechanochemistry of lipid vesicles with implications for drug carrier design. In: JOURNAL OF LIPOSOME RESEARCH. MARCEL DEKKER INC; 2003. p. 103–4.
Needham D. Lipid Membranes: Biological Inspiration for Micro and Nano Encapsulation Technologies, Especially Drug Delivery. Materials Research Society Symposium - Proceedings. 2003 Jan 1;774:173–202.
Hasik MJ, Kim DH, Howle LE, Needham D, Prush DP. Evaluation of synthetic phospholipid ultrasound contrast agents. Ultrasonics. 2002 Nov;40(9):973–82.
Needham D, Lee S. From soft materials to rational design of active carrier delivery systems. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 2002. p. U446–7.
Needham DS, Wong ICK, Campion PD, Hull and East Riding Pharmacy Developmnet Group. Evaluation of the effectiveness of UK community pharmacists' interventions in community palliative care. Palliative medicine. 2002 May;16(3):219–25.
Zhelev DV, Needham D. Interactions of pH-sensitive peptides and polymers with lipid bilayers: Binding and membrane stability. Current Topics in Membranes. 2002 Jan 1;52:437–64.
Needham D, Dewhirst MW. The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. Adv Drug Deliv Rev. 2001 Dec 31;53(3):285–305.
Lee S, Kim DH, Needham D. Equilibrium and Dynamic Interfacial Tension Measurements at Microscopic Interfaces Using a Micropipet Technique. 1. A New Method for Determination of Interfacial Tension. Langmuir. 2001 Sep 4;17(18):5537–43.
Lee S, Kim DH, Needham D. Equilibrium and dynamic interfacial tension measurements at microscopic interfaces using a micropipet technique - 2. Dynamics of phospholipid monolayer formation and equilibrium tensions at the water-air interface. Langmuir. 2001 Sep 4;17(18):5544–50.
Zhelev DV, Stoicheva N, Scherrer P, Needham D. Interaction of synthetic HA2 influenza fusion peptide analog with model membranes. Biophysical journal. 2001 Jul;81(1):285–304.
Zhelev DV, Stoicheva NG, Needham D. Interaction of the amphipatic peptide AcE4K with SOPC membranes. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 2001. p. 531A-531A.
Eichenbaum GM, Kiser PF, Dobrynin AV, Simon SA, Needham D. Erratum: Investigation of the swelling response and loading of ionic microgels with drugs and proteins; The dependence on cross-link density (Macromolecules (July 27, 1999) 32:15 (4867-4878)). Macromolecules. 2001;34(18):6526.
Eichenbaum GM, Kiser PF, Simon SA, Needham D. Erratum: pH and ion-triggered volume responses of anionic hydrogel microspheres (Macromolecules (July 28, 1998) 31:15 (5084-5093)). Macromolecules. 2001;34(20):7230.
Kong G, Anyarambhatla G, Petros WP, Braun RD, Colvin OM, Needham D, et al. Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. Cancer Res. 2000 Dec 15;60(24):6950–7.
Needham D, Kim DH. PEG-covered lipid surfaces: bilayers and monolayers. Colloids and surfaces B, Biointerfaces. 2000 Oct;18(3–4):183–95.
Matteucci ML, Anyarambhatla G, Rosner G, Azuma C, Fisher PE, Dewhirst MW, et al. Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas. Clin Cancer Res. 2000 Sep;6(9):3748–55.
Howell ML, Alsabbagh E, Ma JF, Ochsner UA, Klotz MG, Beveridge TJ, et al. AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide. Journal of bacteriology. 2000 Aug;182(16):4545–56.
Rawicz W, Olbrich KC, McIntosh T, Needham D, Evans E. Effect of chain length and unsaturation on elasticity of lipid bilayers. Biophys J. 2000 Jul;79(1):328–39.
Kiser PF, Wilson G, Needham D. Lipid-coated microgels for the triggered release of doxorubicin. Journal of controlled release : official journal of the Controlled Release Society. 2000 Jul;68(1):9–22.
Olbrich K, Rawicz W, Needham D, Evans E. Water permeability and mechanical strength of polyunsaturated lipid bilayers. Biophys J. 2000 Jul;79(1):321–7.
Eichenbaum GM, Kiser PF, Shah D, Meuer WP, Needham D, Simon SA. Alkali earth metal binding properties of ionic microgels. Macromolecules. 2000 May 30;33(11):4087–93.
Kiser PF, Thomas AA, Eichenbaum GM, Needham D, Kim I. Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable cross-linkers composed of oligo-lactate and oligo-glycolate esters. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 2000. p. U410–U410.
Kim DH, Klibanov AL, Needham D. The influence of tiered layers of surface-grafted poly(ethylene glycol) on receptor-ligand-mediated adhesion between phospholipid monolayer-stabilized microbubbles and coated glass beads. Langmuir. 2000 Mar 21;16(6):2808–17.
Kiser PF, Thomas AA, Eichenbaum GM, Needham D, Kim I. Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 2000 Mar 1;41(1):712–3.
Needham D, Anyarambhatla G, Kong G, Dewhirst MW. A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model. Cancer Res. 2000 Mar 1;60(5):1197–201.
Stoicheva NG, Zhelev DV, Needham D. Exchange of monooleoylphophatidylcholine with membranes containing cholesterol. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 2000. p. 184A-184A.
Needham D, Demurjian S, Peters T. An IDL to Ada95 mapping to support propagation modeling. Ada Lett (USA). 2000;20(1):58–66.
Dewhirst MW, Kong G, Needham D. Use of hyperthermia to augment liposomal drug delivery to tumours. In: Moriaty M, Edington M, Mothersill C, Ward JF, Seymour C, Fry RJM, editors. RADIATION RESEARCH, VOL 2, CONGRESS PROCEEDINGS. ALLEN PRESS INC; 2000. p. 853–6.
Eichenbaum GM, Kiser PF, Shah D, Simon SA, Needham D. Investigation of the swelling response and drug loading of ionic microgels: The dependence on functional group composition. Macromolecules. 1999 Dec 28;32(26):8996–9006.
Mills JK, Needham D. Targeted drug delivery. Expert Opinion on Therapeutic Patents. 1999 Nov 17;9(11):1499–513.
Needham D, Wong I. An expert panel review to evaluate the effectiveness of community pharmacist's interventions in the palliative care setting. In: Pharmaceutical Journal. 1999.
Eichenbaum GM, Kiser PF, Dobrynin AV, Simon SA, Needham D. Investigation of the swelling response and loading of ionic microgels with drugs and proteins: the dependence on cross-link density. Macromolecules. 1999 Jul 27;32(15):4867–78.
Mills JK, Eichenbaum G, Needham D. Effect of bilayer cholesterol and surface grafted poly(ethylene glycol) on pH-induced release of contents from liposomes by poly(2-ethylacrylic acid). Journal of Liposome Research. 1999 Jan 1;9(2):275–90.
Florine-Casteel K, Ritchie K, Ting-Beall HP, Evans E, Needham D. Nanomechanics of the neutrophil interface: Cell surface compliance. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1999. p. A96–A96.
Anyarambhatla GR, Needham D. Enhancement of the phase transition permeability of DPPC liposomes by incorporation of MPPC: A new temperature-sensitive liposome for use with mild hyperthermia. Journal of Liposome Research. 1999 Jan 1;9(4):491–506.
Klibanov AL, Gu H, Wojdyla JK, Wible J, Kim DH, Needham D, et al. Attachment of ligands to gas-filled microbubbles via PEG spacer and lipid residues anchored at the interface. Proceedings of the Controlled Release Society. 1999 Jan 1;(26):124–5.
Needham D. Materials engineering of lipid bilayers for drug carrier performance. MRS Bulletin. 1999 Jan 1;24(10):32–40.
Eichenbaum GM, Kiser PF, Simon SA, Needham D. pH and NaCl triggered response of anionic microgels. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 1998. p. U909–U909.
Florine-Casteel K, Ritchie K, Evans E, Needham D. Nanomechanics of the neutrophil interface: Cell surface compliance. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 1998. p. U674–5.
Eichenbaum GM, Kiser PF, Simon SA, Needham D. Environmental response of anionic microgels. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 1998. p. U871–U871.
Eichenbaum GM, Kiser PF, Simon SA, Needham D. pH and Ion-Triggered Volume Response of Anionic Hydrogel Microspheres. Macromolecules. 1998 Jul 28;31(15):5084–93.
Kiser PF, Wilson G, Needham D. A synthetic mimic of the secretory granule for drug delivery. Nature. 1998 Jul;394(6692):459–62.
Kim DH, Klibanov AL, Evans EA, Needham D. Viscoelastic properties of phospholipid monolayer shells on air microbubbles. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1998. p. A313–A313.
Zhelev DV, Stoicheva N, Needham D. Uptake of fuson peptide by bilayer membranes and mechanical properties of membranes containing fuson peptide. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1998. p. A221–A221.
Olbrich KC, Hutter OF, Needham D. Arachidonic acid increases water permeability of sarcolemmal vesicles from rabbit skeletal muscle. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1998. p. A393–A393.
Needham D, Stoicheva N, Zhelev DV. Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1998. p. A393–A393.
Needham DJ, McAllister S. Centre families in two-dimensional complex holomorphic dynamical systems. Proc R Soc Lond A, Math Phys Eng Sci (UK). 1998;454(1976):2267–78.
Needham D, Mills J, Eichenbaum G. Interactions between poly(2-ethylacrylic acid) and lipid bilayer membranes: effects of cholesterol and grafted poly(ethylene glycol). Faraday discussions. 1998 Jan;(111):103–10.
Needham D, Sarpal RS. Binding of paclitaxel to lipid interfaces: Correlations with interface compliance. Journal of Liposome Research. 1998 Jan 1;8(2):147–63.
Needham D, McIntosh TJ, Simon SA, Zhelev D. Adsorption, molecular exchange and defect formation in membranes. Current Opinion in Colloid and Interface Science. 1998 Jan 1;3(5):511–7.
Needham D, Stoicheva N, Zhelev DV. Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid. Biophysical journal. 1997 Nov;73(5):2615–29.
Evans E, Bowman H, Leung A, Needham D, Tirrell D. Biomembrane templating of nanometer-scale polymer patterns. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 1997. p. 84-PMSE.
Kiser PF, Needham D, Wilson G. Mimicking the smart polymer matrix of the secretory granule: A new concept in controlled release drug delivery. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 1997. p. 134-PMSE.
Needham D, NopplSimson D. Barrier properties of surface-grafted PEG for macromolecule-surface interactions. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 1997. p. 61-POLY.
Needham D, Noppl-Simson D. Barrier properties of surface-grafted PEG for macromolecule-surface interactions. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 1997 Apr 1;38(1):549–50.
TingBeall HP, Kao W, Valentine WM, Needham D. Toxin-induced changes in cell mechanochemical properties. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1997. p. 3160–3160.
Kiser PF, Needham D, Wilson G. Mimicking the smart polymer matrix of the secretory granule: a new concept in controlled release drug delivery. Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. 1997 Jan 1;76:226.
Zhelev DV, Needham D. Pore formation and pore dynamics in bilayer membranes. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 1996 Dec 1;34:47–9.
Evans E, Bowman H, Leung A, Needham D, Tirrell D. Biomembrane templates for nanoscale conduits and networks. Science (New York, NY). 1996 Aug;273(5277):933–5.
Bowman H, Evans E, Needham D, Tirrell D. Nanometer-scale polymeric patterns and networks. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 1996. p. 93-PMSE.
Noppl-Simson DA, Needham D. Avidin-biotin interactions at vesicle surfaces: adsorption and binding, cross-bridge formation, and lateral interactions. Biophysical journal. 1996 Mar;70(3):1391–401.
Olbrich KC, Rawicz W, Evans EA, Needham D. Water permeability and mechanical properties of polyunsaturated lipid membranes. In: BIOPHYSICAL JOURNAL. CELL PRESS; 1996. p. SU340–SU340.
Noppl DA, Needham D. Avidin-biotin interactions at vesicle surfaces: Adsorption and binding, cross bridge formation, and lateral interactions. In: BIOPHYSICAL JOURNAL. CELL PRESS; 1996. p. SU359–SU359.
Needham DJ, King AC, Merkin JH. Reaction-diffusion model for autocatalytic polymerization: II. The initial value problem. IMA Journal of Applied Mathematics (Institute of Mathematics & Its Applications). 1996;56(1):65–86.
Zhelev DV, Needham D. PORE FORMATION AND PORE DYNAMICS IN BILAYER MEMBRANES. In: ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE). 1996. p. 47–9.
Bowman H, Evans E, Needham D, Tirrell DA. Nanometer-scale polymeric patterns and networks. Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. 1996;74:437.
MCINTOSH TJ, NEEDHAM D, ZHELEV DV, SIMON SA. EXPERIMENTAL TESTS FOR MOLECULAR PROTRUSIONS AND UNDULATIONS IN LIPID BILAYERS. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 1995. p. 17-COLL.
McIntosh TJ, Advani S, Burton RE, Zhelev DV, Needham D, Simon SA. Experimental tests for protrusion and undulation pressures in phospholipid bilayers. Biochemistry. 1995 Jul 11;34(27):8520–32.
Hristova K, Needham D. Phase Behavior of a Lipid/Polymer-Lipid Mixture in Aqueous Medium. Macromolecules. 1995 Jul 1;28(4):991–1002.
Needham D, Zhelev DV. Lysolipid exchange with lipid vesicle membranes. Annals of biomedical engineering. 1995 May;23(3):287–98.
Kenworthy AK, Hristova K, Needham D, McIntosh TJ. Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol). Biophys J. 1995 May;68(5):1921–36.
Needham D, Noppl D. Adsorption and adhesion at vesicle surfaces: the influence of grafted polymer on avidin-biotin binding and tests of receptor-mediated adhesion. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 1995 Jan 1;29:331–2.
Needham DJ. Centre theorem for two-dimensional complex holomorphic systems and its generalization. Proceedings of The Royal Society of London, Series A: Mathematical and Physical Sciences. 1995;450(1939):225–32.
Hristova K, Needham D. Influence of bilayer fluctuations on the steric interactions between polymer-grafted bilayers. Liquid Crystals. 1995 Jan 1;18(3):423–30.
Needham D, Zhelev DV. Lysolipid exchange with vesicle membranes and the formation and evolution of porous defects. Annals of Biomedical Engineering. 1995;23(3):287.
Lasic DD, Needham D. The "Stealth" liposome: A prototypical biomaterial. Chemical Reviews. 1995;95(8):2601–28.
Zhelev DV, Needham D, Hochmuth RM. A novel micropipet method for measuring the bending modulus of vesicle membranes. Biophysical journal. 1994 Aug;67(2):720–7.
Zhelev DV, Needham D, Hochmuth RM. Role of the membrane cortex in neutrophil deformation in small pipets. Biophysical journal. 1994 Aug;67(2):696–705.
Simon SA, Disalvo EA, Gawrisch K, Borovyagin V, Toone E, Schiffman SS, et al. Increased adhesion between neutral lipid bilayers: interbilayer bridges formed by tannic acid. Biophys J. 1994 Jun;66(6):1943–58.
KENWORTHY AK, MCINTOSH TJ, HRISTOVA K, NEEDHAM D. STERIC INTERACTIONS BETWEEN GEL AND LIQUID-CRYSTALLINE PHOSPHATIDYLCHOLINE BILAYERS CONTAINING LIPIDS WITH COVALENTLY ATTACHED POLYETHYLENE-GLYCOL. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1994. p. A287–A287.
HRISTOVA K, NEEDHAM D. INCORPORATION OF POLYMER-LIPIDS INTO BILAYERS LEADS TO PHASE-TRANSITION. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1994. p. A177–A177.
Hristova K, Needham D. The Influence of polymer-grafted lipids on the physical properties of lipid bilayers: A theoretical study. Journal of Colloid And Interface Science. 1994 Jan 1;168(2):302–14.
Wu NZ, Klitzman B, Rosner G, Needham D, Dewhirst MW. Measurement of material extravasation in microvascular networks using fluorescence video-microscopy. Microvasc Res. 1993 Sep;46(2):231–53.
Wu NZ, Da D, Rudoll TL, Needham D, Whorton AR, Dewhirst MW. Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue. Cancer Res. 1993 Aug 15;53(16):3765–70.
Ting-Beall HP, Needham D, Hochmuth RM. Volume and osmotic properties of human neutrophils. Blood. 1993 May;81(10):2774–80.
Hochmuth RM, Ting-Beall HP, Beaty BB, Needham D, Tran-Son-Tay R. Viscosity of passive human neutrophils undergoing small deformations. Biophysical journal. 1993 May;64(5):1596–601.
Zhelev DV, Needham D. Tension-stabilized pores in giant vesicles: determination of pore size and pore line tension. Biochimica et biophysica acta. 1993 Apr;1147(1):89–104.
Kavanagh BD, Coffey BE, Needham D, Hochmuth RM, Dewhirst MW. The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment. Br J Cancer. 1993 Apr;67(4):734–41.
HRISTOVA K, NEEDHAM D. THEORETICAL-STUDIES OF MODEL BIOSURFACE PROPERTIES. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1993. p. A298–A298.
ZHELEV DV, NEEDHAM D, HOCHMUTH RM. A NOVEL MICROPIPET TECHNIQUE FOR STUDYING NEUTROPHIL LOCOMOTION, SPREADING AND CONTRACTILITY DURING PHAGOCYTOSIS AND MECHANICALLY STIMULATED POLYMERIZATION OF ACTIN NETWORK. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1993. p. A367–A367.
KENWORTHY AK, MCINTOSH TJ, NEEDHAM D, HRISTOVA K. STERIC INTERACTIONS BETWEEN BILAYERS CONTAINING LIPIDS WITH COVALENTLY ATTACHED POLYETHYLENE-GLYCOL. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1993. p. A348–A348.
ZHELEV DV, NEEDHAM D. LONG LIVED REVERSIBLE PORES IN GIANT LIPOSOMES - A NOVEL METHOD FOR DETERMINATION OF PORE-SIZE AND PORE LINE TENSION. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1993. p. A297–A297.
NEEDHAM D, DA D, RUDOLL TL, TINGBEALL HP, WU N, DEWHIRST MW. PERMEABILITY OF IMPLANTED-TUMOR VASCULATURE TO POLYMER-GRAFTED LIPOSOMES. BIOPHYSICAL JOURNAL. 1993 Feb 1;64(2):A338–A338.
HOCHMUTH RM, TINGBEALL HP, NEEDHAM D, TRANSONTAY R. RECOVERY OF PASSIVE HUMAN NEUTROPHILS AFTER SMALL DEFORMATIONS. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1993. p. A292–A292.
Needham D. Measurement of interbilayer adhesion energies. Methods in enzymology. 1993 Jan;220:111–29.
Sonkin PL, Freedman SF, Needham D, Rao KM, Hatchell DL. Pentoxifylline modulates deformability, F-actin content, and superoxide anion production of polymorphonuclear leukocytes from diabetic cats. Exp Eye Res. 1992 Dec;55(6):831–8.
Needham D, McIntosh TJ, Lasic DD. Repulsive interactions and mechanical stability of polymer-grafted lipid membranes. Biochim Biophys Acta. 1992 Jul 8;1108(1):40–8.
Needham D, Hochmuth RM. A sensitive measure of surface stress in the resting neutrophil. Biophysical journal. 1992 Jun;61(6):1664–70.
LASIC DD, MACLEOD K, HUANG A, ABRA RM, NEWMAN MS, MARTIN FJ, et al. GRAFTED POLYMER (STEALTH) LIPOSOMES. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. AMER CHEMICAL SOC; 1992. p. 51-BIOT.
Simon SA, McIntosh TJ, Magid AD, Needham D. Modulation of the interbilayer hydration pressure by the addition of dipoles at the hydrocarbon/water interface. Biophys J. 1992 Mar;61(3):786–99.
McIntosh TJ, Simon SA, Needham D, Huang CH. Structure and cohesive properties of sphingomyelin/cholesterol bilayers. Biochemistry. 1992 Feb 25;31(7):2012–20.
McIntosh TJ, Simon SA, Needham D, Huang CH. Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers. Biochemistry. 1992 Feb 25;31(7):2020–4.
Needham D, Hristova K, Mcintosh TJ, Dewhirst M, Wu N, Lasic DD. Polymer-grafted liposomes: Physical basis for the "stealth" property. Journal of Liposome Research. 1992 Jan 1;2(3):411–30.
NEEDHAM D, MCINTOSH TJ, SIMON SA. CONFORMATION AND INTERACTIVE PROPERTIES OF SURFACE-BOUND POLYETHYLENE-GLYCOL (PEG) IN LIPID-MEMBRANES AND MONOLAYERS. In: FASEB JOURNAL. FEDERATION AMER SOC EXP BIOL; 1992. p. A237–A237.
Needham DJ. Formal theory concerning the generation and propagation of travelling wave-fronts in reaction-diffusion equations. Quarterly Journal of Mechanics and Applied Mathematics. 1992;45(pt 3):469–98.
Hochmuth RM, Needham D, Ting-Beall HP, Zhelev D. Deformation and flow of neutrophils in micropipets. Annals of Biomedical Engineering. 1991 Dec 1;19(5):568.
Needham D. Morphology, geometry and mechanical properties of GAP A3 hybridoma cells as a function of the cell cycle. Annals of Biomedical Engineering. 1991 Dec 1;19(5):592–3.
Hochmuth RM, Needham D, Ting-Beall HP. Deformation and flow of neutrophils and monocytes. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 1991 Dec 1;20:417–9.
Tran-Son-Tay R, Needham D, Hochmuth RM. Recovery of passive neutrophils after large deformation. Liquid drop model. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 1991 Dec 1;20:421–4.
Needham D, McIntosh TJ. Mechanical and interactive properties of lipid membranes containing surface-bound polymer. Annals of Biomedical Engineering. 1991 Dec 1;19(5):593.
Tran-Son-Tay R, Needham D, Yeung A, Hochmuth RM. Time-dependent recovery of passive neutrophils after large deformation. Biophysical journal. 1991 Oct;60(4):856–66.
Needham D, Ting-Beall HP, Tran-Son-Tay R. A physical characterization of GAP A3 hybridoma cells: morphology, geometry, and mechanical properties. Biotechnology and bioengineering. 1991 Oct;38(8):838–52.
Needham D. Possible role of cell cycle-dependent morphology, geometry, and mechanical properties in tumor cell metastasis. Cell biophysics. 1991 Apr;18(2):99–121.
SONKIN PL, NEEDHAM D, RAO KMK, FREEDMAN SF, HATCHELL DL. PENTOXIFYLLINE IMPROVES DEFORMABILITY AND DECREASES F-ACTIN CONTENT OF PASSIVE POLYMORPHONUCLEAR LEUKOCYTES IN A CAT MODEL OF DIABETES. In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. LIPPINCOTT-RAVEN PUBL; 1991. p. 1288–1288.
Needham D, Ting-Beall HP, Tran-Son-Tay R. Morphology and mechanical properties of gap A3 hybridoma cells as related to cell cycle. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 1990 Dec 1;16:5–10.
Needham D, Nunn RS. Elastic deformation and failure of lipid bilayer membranes containing cholesterol. Biophys J. 1990 Oct;58(4):997–1009.
Needham D, Hochmuth RM. Rapid flow of passive neutrophils into a 4 microns pipet and measurement of cytoplasmic viscosity. Journal of biomechanical engineering. 1990 Aug;112(3):269–76.
Armstrong M, Needham D, Hatchell DL, Nunn RS. Effect of pentoxifylline on the flow of polymorphonuclear leukocytes through a model capillary. Angiology. 1990 Apr;41(4):253–62.
NEEDHAM D, NUNN RS. COHESIVE PROPERTIES (ELASTIC-DEFORMATION AND FAILURE) OF LIPID BILAYERS CONTAINING CHOLESTEROL. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1990. p. A219–A219.
Hochmuth RM, Needham D. The viscosity of neutrophils and their transit times through small pores. Biorheology. 1990 Jan;27(6):817–28.
Needham D, Armstrong M, Hatchell DL, Nunn RS. Rapid deformation of "passive" polymorphonuclear leukocytes: the effects of pentoxifylline. J Cell Physiol. 1989 Sep;140(3):549–57.
Needham D, Hochmuth RM. Electro-mechanical permeabilization of lipid vesicles. Role of membrane tension and compressibility. Biophysical journal. 1989 May;55(5):1001–9.
Needham D, Evans E. Structure and mechanical properties of giant lipid (DMPC) vesicle bilayers from 20 degrees C below to 10 degrees C above the liquid crystal-crystalline phase transition at 24 degrees C. Biochemistry. 1988 Oct;27(21):8261–9.
Needham D, McIntosh TJ, Evans E. Thermomechanical and transition properties of dimyristoylphosphatidylcholine/cholesterol bilayers. Biochemistry. 1988 Jun 28;27(13):4668–73.
NEEDHAM D, EVANS E. STRONG ATTRACTION INDUCED BETWEEN LIPID BILAYER-MEMBRANES BY NON-ADSORBING POLYMERS. In: BIOPHYSICAL JOURNAL. BIOPHYSICAL SOCIETY; 1988. p. A119–A119.
Evans E, Needham D. Attraction between Lipid Bilayer Membranes in Concentrated Solutions of Nonadsorbing Polymers: Comparison of Mean-Field Theory with Measurements of Adhesion Energy. Macromolecules. 1988 Jan 1;21(6):1822–31.
Evans E, Needham D. Physical properties of surfactant bilayer membranes: Thermal transitions, elasticity, rigidity, cohesion, and colloidal interactions. Journal of Physical Chemistry. 1987;91(16):4219–28.
Evans E, Needham D. Giant vesicle bilayers composed of mixtures of lipids, cholesterol and polypeptides. Thermomechanical and (mutual) adherence properties. Faraday discussions of the Chemical Society. 1986 Jan;(81):267–80.
Elliott JR, Haydon DA, Hendry BM, Needham D. Inactivation of the sodium current in squid giant axons by hydrocarbons. Biophysical journal. 1985 Oct;48(4):617–22.
Elliott JR, Needham D, Dilger JP, Brandt O, Haydon DA. A quantitative explanation of the effects of some alcohols on gramicidin single-channel lifetime. Biochimica et biophysica acta. 1985 Apr;814(2):401–4.
Eley DD, Needham D. HYDRIDIZATION AND CATALYSIS BY LANTHANIDE FILMS. Proceedings of The Royal Society of London, Series A: Mathematical and Physical Sciences. 1984;393(1805):257–76.
Elliott JR, Needham D, Dilger JP, Haydon DA. The effects of bilayer thickness and tension on gramicidin single-channel lifetime. Biochimica et biophysica acta. 1983 Oct;735(1):95–103.
Needham D, Haydon DA. Tensions and free energies of formation of "solventless" lipid bilayers. Measurement of high contact angles. Biophysical journal. 1983 Mar;41(3):251–7.

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