Dan Ma

Research Interests

Magnetic Resonance Imaging (MRI), Magnetic Resonance Fingerprinting (MRF)
Fast MRI acquisition design, Image reconstruction, Image post-processing and AI, Clinical applications of MRI

Bio

Our lab is committed to advancing quantitative Magnetic Resonance Imaging (MRI) technology by bridging MR physics, signal modeling, artificial intelligence, and clinical translation. Our goal is to improve the understanding, diagnosis, and treatment of various diseases. Our current research efforts include : 

Magnetic Resonance Fingerprinting (MRF): MRF is a innovative quantitative MR imaging technique developed in our lab, which provides non-invasive quantification of multiple tissue properties within clinically feasible time.

Multi-parametric MR techniques: Developing novel MR acquisition, reconstruction, signal modeling and post-processing techniques.

Clinical translation of quantitative MR: Optimizing and integrating MRF techniques into clinical practice for the early detection and characterization of diseases such as epilepsy, brain tumors, breast cancer, and prostate cancer.

Education

• Ph.D. Case Western Reserve University, School of Medicine, 2015

Positions

• Associate Professor of Neurosurgery
• Associate Professor in Biomedical Engineering

Awards, Honors, and Distinctions

• Senior Member. National Academy of Inventors. 2023
• Junior Fellow. International Society for Magnetic Resonance in Medicine (ISMRM). 2017
• I.I. Rabi Young Investigator Award . International Society for Magnetic Resonance in Medicine (ISMRM). 2016

Publications

• McCullum L, Mulder SL, West NA, Scott H, Rojas DC, Belal Z, et al. Technical Optimization of SyntheticMR for the Head and Neck on a 3T MR-Simulator and 1.5T MR-Linac: A Prospective R-IDEAL Stage 2a Technology Innovation Report. medRxiv. 2025 Apr 10;
• Fuderer M, Wichtmann B, Crameri F, de Souza NM, Baeu00dfler B, Gulani V, et al. Color-map recommendation for MR relaxometry maps. Magn Reson Med. 2025 Feb;93(2):490u2013506.
• Zhu Y, Wang G, Gu Y, Zhao W, Lu J, Zhu J, et al. 3D MR fingerprinting for dynamic contrast-enhanced imaging of whole mouse brain. Magn Reson Med. 2025 Jan;93(1):67u201379.
• Su T-Y, Choi JY, Hu S, Wang X, Blu00fcmcke I, Chiprean K, et al. Multiparametric Characterization of Focal Cortical Dysplasia Using 3D MR Fingerprinting. Ann Neurol. 2024 Nov;96(5):944u201357.
• Hu S, Qiu Z, Adams RJ, Zhao W, Boyacioglu R, Calvetti D, et al. Efficient pulse sequence design framework for high-dimensional MR fingerprinting scans using systematic error index. Magn Reson Med. 2024 Oct;92(4):1600u201316.
• McCullum L, Mulder S, West N, Aghoghovbia R, Ali AMS, Scott H, et al. Technical Development and In Silico Implementation of SyntheticMR in Head and Neck Adaptive Radiation Therapy: A Prospective R-IDEAL Stage 0/1 Technology Development Report. medRxiv. 2024 Sep 30;
• Boudreau M, Karakuzu A, Cohen-Adad J, Bozkurt E, Carr M, Castellaro M, et al. Repeat it without me: Crowdsourcing the T1 mapping common ground via the ISMRM reproducibility challenge. Magn Reson Med. 2024 Sep;92(3):1115u201327.
• Ding Z, Hu S, Su T-Y, Choi JY, Morris S, Wang X, et al. Combining magnetic resonance fingerprinting with voxel-based morphometric analysis to reduce false positives for focal cortical dysplasia detection. Epilepsia. 2024 Jun;65(6):1631u201343.
• Dupuis A, Chen Y, Hansen M, Chow K, Sun JEP, Badve C, et al. Quantifying 3D MR fingerprinting (3D-MRF) reproducibility across subjects, sessions, and scanners automatically using MNI atlases. Magn Reson Med. 2024 May;91(5):2074u201388.
• Ma D, Badve C, Sun JEP, Hu S, Wang X, Chen Y, et al. Motion Robust MR Fingerprinting Scan to Image Neonates With Prenatal Opioid Exposure. J Magn Reson Imaging. 2024 May;59(5):1758u201368.
• Qiu Z, Hu S, Zhao W, Sakaie K, Sun JEP, Griswold MA, et al. Self-calibrated subspace reconstruction for multidimensional MR fingerprinting for simultaneous relaxation and diffusion quantification. Magn Reson Med. 2024 May;91(5):1978u201393.
• Choi JY, Hu S, Su T-Y, Murakami H, Tang Y, Blu00fcmcke I, et al. Normative quantitative relaxation atlases for characterization of cortical regions using magnetic resonance fingerprinting. Cereb Cortex. 2023 Mar 21;33(7):3562u201374.
• Afzali M, Mueller L, Sakaie K, Hu S, Chen Y, Szczepankiewicz F, et al. MR Fingerprinting with b-Tensor Encoding for Simultaneous Quantification of Relaxation and Diffusion in a Single Scan. Magn Reson Med. 2022 Nov;88(5):2043u201357.
• Feng L, Ma D, Liu F. Rapid MR relaxometry using deep learning: An overview of current techniques and emerging trends. NMR Biomed. 2022 Apr;35(4):e4416.
• Chen Y, Lu L, Zhu T, Ma D. Technical overview of magnetic resonance fingerprinting and its applications in radiation therapy. Med Phys. 2022 Apr;49(4):2846u201360.
• Weingu00e4rtner S, Desmond KL, Obuchowski NA, Baessler B, Zhang Y, Biondetti E, et al. Development, validation, qualification, and dissemination of quantitative MR methods: Overview and recommendations by the ISMRM quantitative MR study group. Magn Reson Med. 2022 Mar;87(3):1184u2013206.
• Tippareddy C, Zhao W, Sunshine JL, Griswold M, Ma D, Badve C. Magnetic resonance fingerprinting: an overview. Eur J Nucl Med Mol Imaging. 2021 Dec;48(13):4189u2013200.
• Jordan SP, Hu S, Rozada I, McGivney DF, Boyaciou011flu R, Jacob DC, et al. Automated design of pulse sequences for magnetic resonance fingerprinting using physics-inspired optimization. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40).
• MacAskill CJ, Markley M, Farr S, Parsons A, Perino JR, McBennett K, et al. Rapid B1-Insensitive MR Fingerprinting for Quantitative Kidney Imaging. Radiology. 2021 Aug;300(2):380u20137.
• Boyacioglu R, Wang C, Ma D, McGivney DF, Yu X, Griswold MA. 3D magnetic resonance fingerprinting with quadratic RF phase. Magn Reson Med. 2021 Apr;85(4):2084u201394.
• Dastmalchian S, Kilinc O, Onyewadume L, Tippareddy C, McGivney D, Ma D, et al. Radiomic analysis of magnetic resonance fingerprinting in adult brain tumors. Eur J Nucl Med Mol Imaging. 2021 Mar;48(3):683u201393.
• MacAskill CJ, Erokwu BO, Markley M, Parsons A, Farr S, Zhang Y, et al. Multi-parametric MRI of kidney disease progression for autosomal recessive polycystic kidney disease: mouse model and initial patient results. Pediatr Res. 2021 Jan;89(1):157u201362.
• Hall RC, Ayat NR, Qiao PL, Vaidya AM, Ma D, Aminoshariae A, et al. Preclinical Assessment of the Effectiveness of Magnetic Resonance Molecular Imaging of Extradomain-B Fibronectin for Detection and Characterization of Oral Cancer. Mol Imaging Biol. 2020 Dec;22(6):1532u201342.
• McGivney DF, Boyacu0131ou011flu R, Jiang Y, Poorman ME, Seiberlich N, Gulani V, et al. Magnetic resonance fingerprinting review part 2: Technique and directions. J Magn Reson Imaging. 2020 Apr;51(4):993u20131007.
• Poorman ME, Martin MN, Ma D, McGivney DF, Gulani V, Griswold MA, et al. Magnetic resonance fingerprinting Part 1: Potential uses, current challenges, and recommendations. J Magn Reson Imaging. 2020 Mar;51(3):675u201392.
• Ku00f6rzdu00f6rfer G, Kirsch R, Liu K, Pfeuffer J, Hensel B, Jiang Y, et al. Reproducibility and Repeatability of MR Fingerprinting Relaxometry in the Human Brain. Radiology. 2019 Aug;292(2):429u201337.
• Ma D, Jones SE, Deshmane A, Sakaie K, Pierre EY, Larvie M, et al. Development of high-resolution 3D MR fingerprinting for detection and characterization of epileptic lesions. Journal of Magnetic Resonance Imaging. 2019 May 1;49(5).
• Ma D, Jones SE, Deshmane A, Sakaie K, Pierre EY, Larvie M, et al. Development of high-resolution 3D MR fingerprinting for detection and characterization of epileptic lesions. J Magn Reson Imaging. 2019 May;49(5):1333u201346.
• Deshmane A, McGivney DF, Ma D, Jiang Y, Badve C, Gulani V, et al. Partial volume mapping using magnetic resonance fingerprinting. NMR Biomed. 2019 May;32(5):e4082.
• Ku00f6rzdu00f6rfer G, Jiang Y, Speier P, Pang J, Ma D, Pfeuffer J, et al. Magnetic resonance field fingerprinting. Magn Reson Med. 2019 Apr;81(4):2347u201359.
• Bo Zhao, Haldar JP, Congyu Liao, Dan Ma, Yun Jiang, Griswold MA, et al. Optimal Experiment Design for Magnetic Resonance Fingerprinting: Cramu00e9r-Rao Bound Meets Spin Dynamics. IEEE Trans Med Imaging. 2019 Mar;38(3):844u201361.
• Hamilton JI, Jiang Y, Ma D, Chen Y, Lo W-C, Griswold M, et al. Simultaneous multislice cardiac magnetic resonance fingerprinting using low rank reconstruction. NMR Biomed. 2019 Feb;32(2):e4041.
• Chen Y, Panda A, Pahwa S, Hamilton JI, Dastmalchian S, McGivney DF, et al. Three-dimensional MR Fingerprinting for Quantitative Breast Imaging. Radiology. 2019 Jan;290(1):33u201340.
• de Blank P, Badve C, Gold DR, Stearns D, Sunshine J, Dastmalchian S, et al. Magnetic Resonance Fingerprinting to Characterize Childhood and Young Adult Brain Tumors. Pediatr Neurosurg. 2019;54(5):310u20138.
• Bipin Mehta B, Coppo S, Frances McGivney D, Ian Hamilton J, Chen Y, Jiang Y, et al. Magnetic resonance fingerprinting: a technical review. Magn Reson Med. 2019 Jan;81(1):25u201346.
• Gu Y, Wang CY, Anderson CE, Liu Y, Hu H, Johansen ML, et al. Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice. Magn Reson Med. 2018 Dec;80(6):2681u201390.
• Mehta BB, Ma D, Pierre EY, Jiang Y, Coppo S, Griswold MA. Image reconstruction algorithm for motion insensitive MR Fingerprinting (MRF): MORF. Magn Reson Med. 2018 Dec;80(6):2485u2013500.
• Hamilton JI, Jiang Y, Ma D, Lo W-C, Gulani V, Griswold M, et al. Investigating and reducing the effects of confounding factors for robust T1 and T2 mapping with cardiac MR fingerprinting. Magn Reson Imaging. 2018 Nov;53:40u201351.
• McGivney D, Deshmane A, Jiang Y, Ma D, Badve C, Sloan A, et al. Bayesian estimation of multicomponent relaxation parameters in magnetic resonance fingerprinting. Magn Reson Med. 2018 Jul;80(1):159u201370.
• Wright KL, Jiang Y, Ma D, Noll DC, Griswold MA, Gulani V, et al. Estimation of perfusion properties with MR Fingerprinting Arterial Spin Labeling. Magn Reson Imaging. 2018 Jul;50:68u201377.
• Yang M, Ma D, Jiang Y, Hamilton J, Seiberlich N, Griswold MA, et al. Low rank approximation methods for MR fingerprinting with large scale dictionaries. Magn Reson Med. 2018 Apr;79(4):2392u2013400.
• Ma D, Jiang Y, Chen Y, McGivney D, Mehta B, Gulani V, et al. Fast 3D magnetic resonance fingerprinting for a whole-brain coverage. Magn Reson Med. 2018 Apr;79(4):2190u20137.
• Zhao B, Setsompop K, Adalsteinsson E, Gagoski B, Ye H, Ma D, et al. Improved magnetic resonance fingerprinting reconstruction with low-rank and subspace modeling. Magn Reson Med. 2018 Feb;79(2):933u201342.
• Ma D, Coppo S, Chen Y, McGivney DF, Jiang Y, Pahwa S, et al. Slice profile and B1 corrections in 2D magnetic resonance fingerprinting. Magn Reson Med. 2017 Nov;78(5):1781u20139.
• Jiang Y, Ma D, Bhat H, Ye H, Cauley SF, Wald LL, et al. Use of pattern recognition for unaliasing simultaneously acquired slices in simultaneous multislice MR fingerprinting. Magn Reson Med. 2017 Nov;78(5):1870u20136.
• Jiang Y, Ma D, Keenan KE, Stupic KF, Gulani V, Griswold MA. Repeatability of magnetic resonance fingerprinting T1 and T2 estimates assessed using the ISMRM/NIST MRI system phantom. Magn Reson Med. 2017 Oct;78(4):1452u20137.
• Panda A, Mehta BB, Coppo S, Jiang Y, Ma D, Seiberlich N, et al. Magnetic Resonance Fingerprinting-An Overview. Curr Opin Biomed Eng. 2017 Sep;3:56u201366.
• Ye H, Cauley SF, Gagoski B, Bilgic B, Ma D, Jiang Y, et al. Simultaneous multislice magnetic resonance fingerprinting (SMS-MRF) with direct-spiral slice-GRAPPA (ds-SG) reconstruction. Magn Reson Med. 2017 May;77(5):1966u201374.
• Hamilton JI, Jiang Y, Chen Y, Ma D, Lo W-C, Griswold M, et al. MR fingerprinting for rapid quantification of myocardial T1 , T2 , and proton spin density. Magn Reson Med. 2017 Apr;77(4):1446u201358.
• Hamilton JI, Jiang Y, Chen Y, Ma D, Lo WC, Griswold M, et al. MR fingerprinting for rapid quantification of myocardial T1, T2, and proton spin density. Magnetic Resonance in Medicine. 2017 Apr 1;77(4):C1.
• Jiang Y, Ma D, Jerecic R, Duerk J, Seiberlich N, Gulani V, et al. MR fingerprinting using the quick echo splitting NMR imaging technique. Magn Reson Med. 2017 Mar;77(3):979u201388.
• Badve C, Yu A, Dastmalchian S, Rogers M, Ma D, Jiang Y, et al. MR Fingerprinting of Adult Brain Tumors: Initial Experience. AJNR Am J Neuroradiol. 2017 Mar;38(3):492u20139.
• Pierre EY, Ma D, Chen Y, Badve C, Griswold MA. Multiscale reconstruction for MR fingerprinting. Magn Reson Med. 2016 Jun;75(6):2481u201392.
• Ma D, Pierre EY, Jiang Y, Schluchter MD, Setsompop K, Gulani V, et al. Music-based magnetic resonance fingerprinting to improve patient comfort during MRI examinations. Magn Reson Med. 2016 Jun;75(6):2303u201314.
• Ye H, Ma D, Jiang Y, Cauley SF, Du Y, Wald LL, et al. Accelerating magnetic resonance fingerprinting (MRF) using t-blipped simultaneous multislice (SMS) acquisition. Magn Reson Med. 2016 May;75(5):2078u201385.
• Chen Y, Jiang Y, Pahwa S, Ma D, Lu L, Twieg MD, et al. MR Fingerprinting for Rapid Quantitative Abdominal Imaging. Radiology. 2016 Apr;279(1):278u201386.
• Hamilton JI, Jiang Y, Ma D, Mehta BB, Lo WC, Chen Y, et al. Cardiac MR fingerprinting for T1 and T2 mapping in four heartbeats. Journal of Cardiovascular Magnetic Resonance. 2016 Jan 1;18:1u20133.
• Jiang Y, Ma D, Seiberlich N, Gulani V, Griswold MA. MR fingerprinting using fast imaging with steady state precession (FISP) with spiral readout. Magn Reson Med. 2015 Dec;74(6):1621u201331.
• Cauley SF, Setsompop K, Ma D, Jiang Y, Ye H, Adalsteinsson E, et al. Fast group matching for MR fingerprinting reconstruction. Magn Reson Med. 2015 Aug;74(2):523u20138.
• Gao Y, Chen Y, Ma D, Jiang Y, Herrmann KA, Vincent JA, et al. Preclinical MR fingerprinting (MRF) at 7 T: effective quantitative imaging for rodent disease models. NMR Biomed. 2015 Mar;28(3):384u201394.
• McGivney DF, Pierre E, Ma D, Jiang Y, Saybasili H, Gulani V, et al. SVD compression for magnetic resonance fingerprinting in the time domain. IEEE Trans Med Imaging. 2014 Dec;33(12):2311u201322.
• Barkauskas KJ, Rajiah P, Ashwath R, Hamilton JI, Chen Y, Ma D, et al. Quantification of left ventricular functional parameter values using 3D spiral bSSFP and through-time non-Cartesian GRAPPA. J Cardiovasc Magn Reson. 2014 Sep 11;16(1):65.
• Ma D, Gulani V, Seiberlich N, Liu K, Sunshine JL, Duerk JL, et al. Magnetic resonance fingerprinting. Nature. 2013 Mar 14;495(7440):187u201392.
• Ma D, Wolf P, Clough AV, Schmidt TG. The performance of MLEM for dynamic imaging from simulated few-view, multi-pinhole SPECT. IEEE Trans Nucl Sci. 2013 Feb;60(1).
• Ehses P, Seiberlich N, Ma D, Breuer FA, Jakob PM, Griswold MA, et al. IR TrueFISP with a golden-ratio-based radial readout: fast quantification of T1, T2, and proton density. Magn Reson Med. 2013 Jan;69(1):71u201381.
• Ma D, Clough AV, Schmidt TG. Multi-pinhole dynamic SPECT imaging: Simulation and system optimization. In: Progress in Biomedical Optics and Imaging Proceedings of SPIE. 2010.