Sharon Gerecht

Research Interests

regenerative medicine, stem cells, biomaterials, hypoxia, blood vessels, physics of cancer

Bio

Dr. Gerecht is an internationally recognized pioneer in stem cells and vascular biology and engineering. Gerecht’s research group studies how the microenvironment regulates cellular responses, with the long-term goal of developing countermeasures and therapeutics. We emulate mechanical and physical stressors toward understanding tissue function, reliance, and homeostasis. We use that information to uncover pathways in injury and disease development to guide tissue healing and regeneration. We focus on blood vessels and their multifaceted roles in tissue performance, aging, and disease. 

Education

• Ph.D. Israel Institute of Technology (Israel), 2004

Positions

• Paul M. Gross Distinguished Professor
• Professor of Biomedical Engineering
• Chair of the Department of Biomedical Engineering
• Member of the Duke Cancer Institute

Awards, Honors, and Distinctions

• Fellow . American Heart Association. 2024
• Member. National Academy of Inventors. 2020
• Fellow. American Association for the Advancement of Science (AAAS). 2020
• Member. National Academy of Medicine. 2019
• Invitee. Inaugural 2019 NAM Emerging Leaders Forum. 2019
• Recipient. Patrick C. Walsh Prostate Cancer Research Fund. 2017
• Fellow. American Institute for Medical and Biological Engineering (AIBME). 2016
• Scholar. Inaugural Kent Gordon Croft Investment Management Faculty Scholar. 2015
• National Established Investigator Award. American Heart Association. 2015
• Inaugural President's Frontier Award. Johns Hopkins University. 2015
• Heart Award. W.W. Smith Charitable Trust. 2014
• CAREER Award. National Science Foundation (NSF). 2011
• Basil Ou2019Connor Starter Scholar Research Award. March of Dimes Foundation. 2009
• Junior Investigator Award. North American Vascular Biology Organization (NAVBO). 2009
• National Scientist Development Award. American Heart Association. 2008
• Allan C. Davis Medal, Outstanding Young Engineering Award. Maryland Academy of Sciences. 2008

Courses Taught

• EGR 393: Research Projects in Engineering
• BME 890: Advanced topics for PhD students
• BME 792: Continuation of Graduate Independent Study
• BME 791: Graduate Independent Study
• BME 644: Physiology for Engineers
• BME 494: Projects in Biomedical Engineering (GE)
• BME 493: Projects in Biomedical Engineering (GE)
• BME 394: Projects in Biomedical Engineering (GE)

Publications

• Guan Y, Zhang M, Song J, Negrete M, Adcock T, Kandel R, et al. CaMKK2 Regulates Macrophage Polarization Induced by Matrix Stiffness: Implications for Shaping the Immune Response in Stiffened Tissues. Adv Sci (Weinh). 2025 Mar 4;e2417778.
• Anderson AR, Caston ELP, Riley L, Nguyen L, Ntekoumes D, Gerecht S, et al. Engineering the Microstructure and Spatial Bioactivity of MAP Scaffolds Instructs Vasculogenesis In Vitro and Modifies Vessel Formation In Vivo. Advanced Functional Materials. 2025 Jan 15;35(3).
• Ntekoumes D, Song J, Liu H, Amelung C, Guan Y, Gerecht S. Acute Three-Dimensional Hypoxia Regulates Angiogenesis. Advanced healthcare materials. 2025 Jan;14(2):e2403860.
• Villares E, Gerecht S. Engineered Biomaterials and Model Systems to Study YAP/TAZ in Cancer. ACS biomaterials science & engineering. 2024 Sep;10(9):5550u201361.
• Hall FD, Miller CN, Gerecht S, Boheler KR. Generation of an induced pluripotent stem cell line, JHUi005-A, from a Marfan Syndrome patient harboring a pathogenic c.3338-2A>C intronic splicing variant. Stem cell research. 2024 Sep;79:103475.
• Brady T, Gerecht S, Santhanam L. Functional profiling of resident cells during vascular aging. In: Physiology. American Physiological Society; 2024.
• Fuller AM, Pruitt HC, Liu Y, Irizarry-Negron VM, Pan H, Song H, et al. Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment. The Journal of clinical investigation. 2024 Apr;134(11):e167826.
• Wei Z, Lei M, Wang Y, Xie Y, Xie X, Lan D, et al. Author Correction: Hydrogels with tunable mechanical plasticity regulate endothelial cell outgrowth in vasculogenesis and angiogenesis. Nature communications. 2024 Apr;15(1):3274.
• Marino-Bravante GE, Carey AE, Hu00fcser L, Dixit A, Wang V, Kaur A, et al. Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma. Nature aging. 2024 Mar;4(3):350u201363.
• Tran AT, Wisniewski EO, Mistriotis P, Stoletov K, Parlani M, Amitrano A, et al. Cytoplasmic accumulation and plasma membrane association of anillin and Ect2 promote confined migration and invasion. Res Sq. 2024 Jan 10;
• Correction for Eisinger-Mathason et al., Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis. Proceedings of the National Academy of Sciences. 2024 Jan 9;121(2).
• Shah S, Song J, Samanta BR, Sarkar S, Crouch MS, Eggleston MS, et al. In Vivo Evaluation of Hydrogel-Mediated Wound Healing Using Optical Coherence Tomography. In: Optical Coherence Tomography, OCT 2024 in Proceedings Optica Biophotonics Congress: Biomedical Optics 2024, Translational, Microscopy, OCT, OTS, BRAIN - Part of Optica Biophotonics Congress: Biomedical Optics. 2024.
• Shah S, Song J, Samanta BR, Sarkar S, Crouch MS, Eggleston MS, et al. In Vivo Evaluation of Hydrogel-Mediated Wound Healing Using Optical Coherence Tomography. In: Optical Coherence Tomography, OCT 2024 in Proceedings Optica Biophotonics Congress: Biomedical Optics 2024, Translational, Microscopy, OCT, OTS, BRAIN - Part of Optica Biophotonics Congress: Biomedical Optics. 2024.
• Wei Z, Lei M, Wang Y, Xie Y, Xie X, Lan D, et al. Hydrogels with tunable mechanical plasticity regulate endothelial cell outgrowth in vasculogenesis and angiogenesis. Nature communications. 2023 Dec;14(1):8307.
• Guan Y, Racioppi L, Gerecht S. Engineering biomaterials to tailor the microenvironment for macrophageu2013endothelium interactions. Nature Reviews Materials. 2023 Oct 1;8(10):688u201399.
• Hemmati F, Akinpelu A, Song J, Amiri F, McDaniel A, McMurray C, et al. Downregulation of YAP Activity Restricts P53 Hyperactivation to Promote Cell Survival in Confinement. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023 Aug;10(23):e2302228.
• Song J, Gerecht S. Hydrogels to Recapture Extracellular Matrix Cues That Regulate Vascularization. Arteriosclerosis, thrombosis, and vascular biology. 2023 Aug;43(8):e291u2013302.
• Pruitt HC, Guan Y, Liu H, Carey AE, Brennen WN, Lu J, et al. Collagen VI deposition mediates stromal T cell trapping through inhibition of T cell motility in the prostate tumor microenvironment. Matrix biologyu202f: journal of the International Society for Matrix Biology. 2023 Aug;121:90u2013104.
• Wang D, Brady T, Santhanam L, Gerecht S. The extracellular matrix mechanics in the vasculature. Nature cardiovascular research. 2023 Aug;2(8):718u201332.
• Schnellmann R, Gerecht S. Reconstructing the ageing extracellular matrix. Nature Reviews Bioengineering. 2023 Jul 1;1(7):458u20139.
• Brady T, Santhanam L, Gerecht S. Effect of ECM and mechanical strain on vascular cell plasticity. In: Physiology. American Physiological Society; 2023.
• Volkova E, Procell L, Kong L, Santhanam L, Gerecht S. Vascular stiffening in aging females with a hypertension-induced HIF2A gain-of-function mutation. Bioengineering & translational medicine. 2023 Mar;8(2):e10403.
• Warren E, Gerecht S. BEYOND THE ENDOTHELIUM: THE ROLE OF MURAL CELLS IN VASCULAR BIOLOGY: In vitro systems to study endothelial/pericyte cell interactions. Vascular biology (Bristol, England). 2023 Feb;5(1):e220021.
• Chavez T, Gerecht S. Engineering of the microenvironment to accelerate vascular regeneration. Trends in molecular medicine. 2023 Jan;29(1):35u201347.
• Wei Z, Lei M, Wang Y, Xie Y, Xie X, Lan D, et al. Hydrogels with Tunable Mechanical Plasticity Regulate Endothelial Cell Outgrowth in Vasculogenesis and Angiogenesis. Research Square. 2023.
• Bokhari RS, Beheshti A, Blutt SE, Bowles DE, Brenner D, Britton R, et al. Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sci Space Res (Amst). 2022 Nov;35:105u201312.
• Elliott MB, Matsushita H, Shen J, Yi J, Inoue T, Brady T, et al. Off-the-shelf, heparinized small diameter vascular graft limits acute thrombogenicity in a porcine model. Acta biomaterialia. 2022 Oct;151:134u201347.
• Isser A, Silver AB, Pruitt HC, Mass M, Elias EH, Aihara G, et al. Nanoparticle-based modulation of CD4⁺ T cell effector and helper functions enhances adoptive immunotherapy. Nature communications. 2022 Oct;13(1):6086.
• Yarbrough D, Gerecht S. Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease. Bioengineering (Basel, Switzerland). 2022 Sep;9(9):449.
• Schnellmann R, Ntekoumes D, Choudhury MI, Sun S, Wei Z, Gerecht S. Stiffening Matrix Induces Age-Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 Aug;9(22):e2201483.
• Ntekoumes D, Gerecht S. Tissue Engineering Approaches to Uncover Therapeutic Targets for Endothelial Dysfunction in Pathological Microenvironments. International journal of molecular sciences. 2022 Jul;23(13):7416.
• Jamieson JJ, Lin Y, Malloy N, Soto D, Searson PC, Gerecht S. Hypoxia-induced blood-brain barrier dysfunction is prevented by pericyte-conditioned media via attenuated actomyosin contractility and claudin-5 stabilization. FASEB journalu202f: official publication of the Federation of American Societies for Experimental Biology. 2022 May;36(5):e22331.
• Macklin BL, Lin Y-Y, Emmerich K, Wisniewski E, Polster BM, Konstantopoulos K, et al. Intrinsic epigenetic control of angiogenesis in induced pluripotent stem cell-derived endothelium regulates vascular regeneration. NPJ Regenerative medicine. 2022 May;7(1):28.
• Fuller AM, Pruitt HC, Song H, Liu Y, Devine A, Katti RS, et al. Oncogene-induced matrix reorganization controls CD8⁺ T cell immunity in the UPS microenvironment. In: CLINICAL CANCER RESEARCH. 2022.
• Fuller A, Pruitt H, Liu Y, Irizarry-Negron V, Pan H, Song H, et al. Oncogene-induced matrix reorganization controls CD8⁺T cell function in the soft-tissue sarcoma microenvironment. bioRxiv. 2022.
• Elliott MB, Ginn B, Fukunishi T, Bedja D, Suresh A, Chen T, et al. Erratum: Regenerative and durable small-diameter graft as an arterial conduit(Proceedings of the National Academy of Sciences of the United States of America (2019) 116 (12710u201312719) DOI: 10.1073/pnas.1905966116). Proceedings of the National Academy of Sciences of the United States of America. 2021 Sep 14;118(37).
• Blatchley MR, Hall F, Ntekoumes D, Cho H, Kailash V, Vazquez-Duhalt R, et al. Discretizing Three-Dimensional Oxygen Gradients to Modulate and Investigate Cellular Processes. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2021 Jul;8(14):e2100190.
• Nguyen J, Lin Y-Y, Gerecht S. The next generation of endothelial differentiation: Tissue-specific ECs. Cell stem cell. 2021 Jul;28(7):1188u2013204.
• Chan XY, Volkova E, Eoh J, Black R, Fang L, Gorashi R, et al. HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics. iScience. 2021 Apr;24(4):102246.
• Gerecht S, Narasimhan B. Editorial overview: Biological engineering: complex biological barriers: Transport mechanisms of diverse payloads across complex biological barriers. Current Opinion in Chemical Engineering. 2021 Mar 1;31.
• Pruitt HC, Gerecht S. Modeling metastasis: Engineering approaches to study the metastatic cascade. Progress in Biomedical Engineering. 2021 Feb 5;3(1).
• Wei Z, Schnellmann R, Pruitt HC, Gerecht S. Hydrogel Network Dynamics Regulate Vascular Morphogenesis. Cell stem cell. 2020 Nov;27(5):798-812.e6.
• Lowenthal J, Gerecht S. If You Build It, They Will Come: Towards Self-Assembly of Functional Cardiovascular Tissues. Circulation research. 2020 Jul;127(2):225u20138.
• Jia J, Jeon EJ, Li M, Richards DJ, Lee S, Jung Y, et al. Evolutionarily conserved sequence motif analysis guides development of chemically defined hydrogels for therapeutic vascularization. Science advances. 2020 Jul;6(28):eaaz5894.
• Schnellmann R, Wei Z, Choudhury MI, Sun S, Gerecht S. Vascular Phenotype is Compromised in Dynamically Stiffening Hydrogel. In: The FASEB Journal. Wiley; 2020. p. 1u20131.
• Cho H, Macklin BL, Lin Y-Y, Zhou L, Lai MJ, Lee G, et al. iPSC-derived endothelial cell response to hypoxia via SDF1a/CXCR4 axis facilitates incorporation to revascularize ischemic retina. JCI insight. 2020 Mar;5(6):131828.
• Pitaktong I, Lui C, Lowenthal J, Mattson G, Jung W-H, Bai Y, et al. Early Vascular Cells Improve Microvascularization Within 3D Cardiac Spheroids. Tissue engineering Part C, Methods. 2020 Feb;26(2):80u201390.
• Khademhosseini A, Ashammakhi N, Karp JM, Gerecht S, Ferreira L, Annabi N, et al. Embryonic stem cells as a cell source for tissue engineering. In: Principles of Tissue Engineering. 2020. p. 467u201390.
• Pruitt HC, Lewis D, Ciccaglione M, Connor S, Smith Q, Hickey JW, et al. Collagen fiber structure guides 3D motility of cytotoxic T lymphocytes. Matrix biologyu202f: journal of the International Society for Matrix Biology. 2020 Jan;85u201386:147u201359.
• Blatchley MR, Gerecht S. Reconstructing the Vascular Developmental Milieu Inu00a0Vitro. Trends in cell biology. 2020 Jan;30(1):15u201331.
• Wei Z, Volkova E, Blatchley MR, Gerecht S. Hydrogel vehicles for sequential delivery of protein drugs to promote vascular regeneration. Advanced drug delivery reviews. 2019 Sep;149u2013150:95u2013106.
• Xiao Y, Liu C, Chen Z, Blatchley MR, Kim D, Zhou J, et al. Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs. Advanced biosystems. 2019 Aug;3(8):1900089.
• Cho H, Blatchley MR, Duh EJ, Gerecht S. Acellular and cellular approaches to improve diabetic wound healing. Advanced drug delivery reviews. 2019 Jun;146:267u201388.
• Elliott MB, Ginn B, Fukunishi T, Bedja D, Suresh A, Chen T, et al. Regenerative and durable small-diameter graft as an arterial conduit. Proceedings of the National Academy of Sciences of the United States of America. 2019 Jun;116(26):12710u20139.
• Jamieson JJ, Linville RM, Ding YY, Gerecht S, Searson PC. Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D. Fluids and barriers of the CNS. 2019 Jun;16(1):15.
• Hickey JW, Dong Y, Chung JW, Salathe SF, Pruitt HC, Li X, et al. Engineering an Artificial T-Cell Stimulating Matrix for Immunotherapy. Advanced materials (Deerfield Beach, Fla). 2019 Jun;31(23):e1807359.
• Jamieson JJ, Gerecht S. Chipping Away at Blood-Brain-Barrier Modeling. Cell stem cell. 2019 Jun;24(6):831u20132.
• Blazeski A, Lowenthal J, Wang Y, Teuben R, Zhu R, Gerecht S, et al. Engineered Heart Slice Model of Arrhythmogenic Cardiomyopathy Using Plakophilin-2 Mutant Myocytes. Tissue engineering Part A. 2019 May;25(9u201310):725u201335.
• Lewis DM, Pruitt H, Jain N, Ciccaglione M, McCaffery JM, Xia Z, et al. A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma. Cancer research. 2019 Apr;79(8):1981u201395.
• Blatchley MR, Hall F, Wang S, Pruitt HC, Gerecht S. Hypoxia and matrix viscoelasticity sequentially regulate endothelial progenitor cluster-based vasculogenesis. Science advances. 2019 Mar;5(3):eaau7518.
• Wei Z, Gerecht S. Hydrogels with self-healing abilities as injectable carriers for vasculogenesis. In: Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium. 2019. p. 477.
• Lowenthal J, Blazeski A, Hawthorne R, Teuben R, DiSilvestre D, Tomaselli GF, et al. Pairing Improved Maturation With Metabolic Stress Reveals Disease-Like Features in Tissue Models of Arrhythmogenic Cardiomyopathy. In: CIRCULATION. 2019.
• Wei Z, Gerecht S. A self-healing hydrogel as an injectable instructive carrier for cellular morphogenesis. Biomaterials. 2018 Dec;185:86u201396.
• Smith Q, Macklin B, Chan XY, Jones H, Trempel M, Yoder MC, et al. Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells. Cell reports. 2018 Aug;24(7):1930.
• Smith Q, Rochman N, Carmo AM, Vig D, Chan XY, Sun S, et al. Cytoskeletal tension regulates mesodermal spatial organization and subsequent vascular fate. Proceedings of the National Academy of Sciences of the United States of America. 2018 Aug;115(32):8167u201372.
• Lewis DM, Mavrogiannis N, Gagnon Z, Gerecht S. Microfluidic platform for the real time measurement and observation of endothelial barrier function under shear stress. Biomicrofluidics. 2018 Jul;12(4):042202.
• Jaber SM, Bordt EA, Bhatt NM, Lewis DM, Gerecht S, Fiskum G, et al. Sex differences in the mitochondrial bioenergetics of astrocytes but not microglia at a physiologically relevant brain oxygen tension. Neurochemistry international. 2018 Jul;117:82u201390.
• Smith Q, Macklin B, Chan XY, Jones H, Trempel M, Yoder MC, et al. Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells. Cell reports. 2018 Jul;24(4):895-908.e6.
• Gerecht S. Oxygen in cancer and neovascularization. In: Free Radical Biology and Medicine. Elsevier BV; 2018. p. S10u2013S10.
• Chan XY, Eoh JH, Gerecht S. Let's get physical: Biomechanical influences on human pluripotent stem cell differentiation towards vascular engineering. Current Opinion in Biomedical Engineering. 2018 Mar 1;5:42u20139.
• Maynard JA, Gerecht S. Editorial overview - Biological engineering: Emerging strategies to understand and engineer the human immune system. Current Opinion in Chemical Engineering. 2018 Mar 1;19:iu2013iii.
• Smith Q, Gerecht S. Extracellular Matrix Regulation of Stem Cell Fate. Current Stem Cell Reports. 2018 Mar 1;4(1):13u201321.
• Lewis DM, Tang V, Jain N, Isser A, Xia Z, Gerecht S. Collagen Fiber Architecture Regulates Hypoxic Sarcoma Cell Migration. ACS biomaterials science & engineering. 2018 Feb;4(2):400u20139.
• Jamieson J, Macklin B, Gerecht S. Pericytes Derived from Human Pluripotent Stem Cells. Advances in experimental medicine and biology. 2018 Jan;1109:111u201324.
• Chan XY, Elliott MB, Macklin B, Gerecht S. Human Pluripotent Stem Cells to Engineer Blood Vessels. Advances in biochemical engineering/biotechnology. 2018 Jan;163:147u201368.
• Blatchley MR, Abaci HE, Hanjaya-Putra D, Gerecht S. Hypoxia and Matrix Manipulation for Vascular Engineering. In: Biological and Medical Physics, Biomedical Engineering. Springer International Publishing; 2018. p. 73u2013119.
• Gerecht S. Biophysical Regulation of Vascular Differentiation and Assembly Second Edition Preface. In: BIOPHYSICAL REGULATION OF VASCULAR DIFFERENTIATION AND ASSEMBLY, 2ND EDITION. 2018. p. VIIu2013VIII.
• Lewis DM, Blatchley MR, Park KM, Gerecht S. O₂-controllable hydrogels for studying cellular responses to hypoxic gradients in three dimensions in vitro and in vivo. Nature protocols. 2017 Aug;12(8):1620u201338.
• Wei Z, Lewis DM, Xu Y, Gerecht S. Dual Cross-Linked Biofunctional and Self-Healing Networks to Generate User-Defined Modular Gradient Hydrogel Constructs. Advanced healthcare materials. 2017 Aug;6(16).
• Blatchley MR, Gerecht S. Integrin binding: Sticking around vessels. Nature materials. 2017 Aug;16(9):881u20133.
• Lewis DM, Gerecht S, Eisinger-Mathason TSK. Abstract 5477: Hydrogels to study ECM-oxygen gradient interactions for sarcoma cell migration. In: Cancer Research. American Association for Cancer Research (AACR); 2017. p. 5477u20135477.
• Park KM, Lewis D, Gerecht S. Bioinspired Hydrogels to Engineer Cancer Microenvironments. Annual review of biomedical engineering. 2017 Jun;19:109u201333.
• Smith Q, Chan XY, Carmo AM, Trempel M, Saunders M, Gerecht S. Compliant substratum guides endothelial commitment from human pluripotent stem cells. Science advances. 2017 May;3(5):e1602883.
• Smith Q, Blatchley M, Gerecht S. Engineering Niches for Blood Vessel Regeneration. In: Biology and Engineering of Stem Cell Niches. 2017. p. 479u201397.
• Eoh JH, Shen N, Burke JA, Hinderer S, Xia Z, Schenke-Layland K, et al. Enhanced elastin synthesis and maturation in human vascular smooth muscle tissue derived from induced-pluripotent stem cells. Acta biomaterialia. 2017 Apr;52:49u201359.
• Kusuma S, Smith Q, Facklam A, Gerecht S. Micropattern size-dependent endothelial differentiation from a human induced pluripotent stem cell line. Journal of tissue engineering and regenerative medicine. 2017 Mar;11(3):855u201361.
• Gerecht S, Konstantopoulos K. Editorial overview: Biological engineering: Stem cell engineering. Current Opinion in Chemical Engineering. 2017 Feb 1;15:iu2013ii.
• Lewis DM, Park KM, Eisinger-Mathason TSK, Simon C, Gerecht S. Abstract B61: Intratumoral oxygen gradients mediate sarcoma cell invasion. In: Cancer Research. American Association for Cancer Research (AACR); 2017. p. B61u2013B61.
• Macklin BL, Gerecht S. Bridging the gap: induced pluripotent stem cell derived endothelial cells for 3D vascular assembly. Current Opinion in Chemical Engineering. 2017 Jan 1;15:102u20139.
• Rochman ND, Smith Q, Carmo AM, Vig DK, Sun SX, Gerecht S. T is for Tension: Micropatterns, Machine Learning, and the Role of the Microenvironment in Mesoderm Induction. In: MOLECULAR BIOLOGY OF THE CELL. 2017.
• Smith Q, Chan XY, Carmo A, Vig D, Sun S, Gerecht S. Engineering mechanical cues in the stem cell differentiation niche: Applications in vascular tissue engineering. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2017.
• Jamieson JJ, Searson PC, Gerecht S. Engineering the human blood-brain barrier in vitro. Journal of biological engineering. 2017 Jan;11:37.
• Duncan GA, Gerecht S, Fairbrother DH, Bevan MA. Diffusing Colloidal Probes of kT-Scale Biomaterial-Cell Interactions. Langmuiru202f: the ACS journal of surfaces and colloids. 2016 Nov;32(46):12212u201320.
• Shen Y-I, Cho H, Papa AE, Burke JA, Chan XY, Duh EJ, et al. Engineered human vascularized constructs accelerate diabetic wound healing. Biomaterials. 2016 Sep;102:107u201319.
• Smith Q, Gerecht S. Stem Cell Fate Is a Touchy Subject. Cell stem cell. 2016 Sep;19(3):289u201390.
• Lewis DM, Park KM, Tang V, Xu Y, Pak K, Eisinger-Mathason TSK, et al. Intratumoral oxygen gradients mediate sarcoma cell invasion. Proceedings of the National Academy of Sciences of the United States of America. 2016 Aug;113(33):9292u20137.
• Elliott MB, Gerecht S. Three-dimensional culture of small-diameter vascular grafts. Journal of materials chemistry B. 2016 May;4(20):3443u201353.
• Lowenthal J, Gerecht S. Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering. Biochemical and biophysical research communications. 2016 May;473(3):733u201342.
• Gerecht S, Konstantopoulos K. Editorial overview: Biological engineering: Engineering systems for cancer modeling, diagnostics and therapeutics. Current Opinion in Chemical Engineering. 2016 Feb 1;11:ivu2013v.
• Lewis DM, Gerecht S. Microfluidics and biomaterials to study angiogenesis. Current Opinion in Chemical Engineering. 2016 Feb 1;11:114u201322.
• Kusuma S, Gerecht S. Derivation of Endothelial Cells and Pericytes from Human Pluripotent Stem Cells. Methods in molecular biology (Clifton, NJ). 2016 Jan;1307:213u201322.
• Hielscher A, Ellis K, Qiu C, Porterfield J, Gerecht S. Fibronectin Deposition Participates in Extracellular Matrix Assembly and Vascular Morphogenesis. PloS one. 2016 Jan;11(1):e0147600.
• Burdick JA, Mauck RL, Gerecht S. To Serve and Protect: Hydrogels to Improve Stem Cell-Based Therapies. Cell stem cell. 2016 Jan;18(1):13u20135.
• Lowenthal J, Blazeski A, Chan XY, Gerecht S, Tung L. Directed Differentiation of Cardiac and Vascular Lineages from Pluripotent Stem Cells on Decellularized Myocardial Matrix. In: TISSUE ENGINEERING PART A. 2016. p. S93u2013S93.
• Gerecht S. Mimicking the Microenvironment. In: Science Policy Reports. Springer International Publishing; 2016. p. 31u201348.
• Dickinson LE, Gerecht S. Engineered Biopolymeric Scaffolds for Chronic Wound Healing. Frontiers in physiology. 2016 Jan;7:341.
• Katt ME, Xu ZS, Gerecht S, Searson PC. Human Brain Microvascular Endothelial Cells Derived from the BC1 iPS Cell Line Exhibit a Blood-Brain Barrier Phenotype. PloS one. 2016 Jan;11(4):e0152105.
• Chan XY, Black R, Dickerman K, Federico J, Lu00e9vesque M, Mumm J, et al. Three-Dimensional Vascular Network Assembly From Diabetic Patient-Derived Induced Pluripotent Stem Cells. Arteriosclerosis, thrombosis, and vascular biology. 2015 Dec;35(12):2677u201385.
• Lewis DM, Abaci HE, Xu Y, Gerecht S. Endothelial progenitor cell recruitment in a microfluidic vascular model. Biofabrication. 2015 Dec;7(4):045010.
• Bogorad MI, DeStefano J, Karlsson J, Wong AD, Gerecht S, Searson PC. Review: in vitro microvessel models. Lab on a chip. 2015 Nov;15(22):4242u201355.
• Shen Y-I, Song H-HG, Papa A, Burke J, Volk SW, Gerecht S. Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model. The Journal of investigative dermatology. 2015 Oct;135(10):2519u201329.
• Blatchley M, Park KM, Gerecht S. Designer Hydrogels for Precision Control of Oxygen Tension and Mechanical Properties. Journal of materials chemistry B. 2015 Oct;3(40):7939u201349.
• Barreto-Ortiz SF, Fradkin J, Eoh J, Trivero J, Davenport M, Ginn B, et al. Fabrication of 3-dimensional multicellular microvascular structures. FASEB journalu202f: official publication of the Federation of American Societies for Experimental Biology. 2015 Aug;29(8):3302u201314.
• Wanjare M, Agarwal N, Gerecht S. Biomechanical strain induces elastin and collagen production in human pluripotent stem cell-derived vascular smooth muscle cells. American journal of physiology Cell physiology. 2015 Aug;309(4):C271u201381.
• Eisinger TSK, Mucaj V, Biju K, Nakazawa M, Gohil M, Cash T, et al. Abstract 960: Deregulation of the Hippo pathway in soft tissue sarcoma promotes FOXM1 expression and tumorigenesis. In: Cancer Research. American Association for Cancer Research (AACR); 2015. p. 960u2013960.
• Smith Q, Stukalin E, Kusuma S, Gerecht S, Sun SX. Stochasticity and Spatial Interaction Govern Stem Cell Differentiation Dynamics. Scientific reports. 2015 Jul;5:12617.
• Park KM, Gerecht S. Polymeric hydrogels as artificial extracellular microenvironments for cancer research. European Polymer Journal. 2015 Jun 29;72:507u201313.
• Eisinger-Mathason TSK, Mucaj V, Biju KM, Nakazawa MS, Gohil M, Cash TP, et al. Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 2015 Jun;112(26):E3402u201311.
• Blatchley MR, Gerecht S. Acellular implantable and injectable hydrogels for vascular regeneration. Biomedical materials (Bristol, England). 2015 Mar;10(3):034001.
• Kusuma S, Facklam A, Gerecht S. Characterizing human pluripotent-stem-cell-derived vascular cells for tissue engineering applications. Stem cells and development. 2015 Feb;24(4):451u20138.
• Hielscher A, Gerecht S. Hypoxia and free radicals: role in tumor progression and the use of engineering-based platforms to address these relationships. Free radical biology & medicine. 2015 Feb;79:281u201391.
• Gerecht S. Controlling Microvascular Assembly. In: TISSUE ENGINEERING PART A. 2015. p. S22u2013S22.
• Song H-HG, Park KM, Gerecht S. Hydrogels to model 3D in vitro microenvironment of tumor vascularization. Advanced drug delivery reviews. 2014 Dec;79u201380:19u201329.
• Park KM, Gerecht S. Biomaterials as Artificial Niches for Pluripotent Stem Cell Engineering. In: Cell and Molecular Biology and Imaging of Stem Cells. 2014. p. 21u201343.
• Park KM, Blatchley MR, Gerecht S. The design of dextran-based hypoxia-inducible hydrogels via in situ oxygen-consuming reaction. Macromolecular rapid communications. 2014 Nov;35(22):1968u201375.
• Wang Y, Cheng L, Gerecht S. Efficient and scalable expansion of human pluripotent stem cells under clinically compliant settings: a view in 2013. Annals of biomedical engineering. 2014 Jul;42(7):1357u201372.
• Park KM, Gerecht S. Harnessing developmental processes for vascular engineering and regeneration. Development (Cambridge, England). 2014 Jul;141(14):2760u20139.
• Park KM, Gerecht S. Hypoxia-inducible hydrogels. Nature communications. 2014 Jun;5:4075.
• Stahl PJ, Chan TR, Shen Y-I, Sun G, Gerecht S, Yu SM. Capillary Network-Like Organization of Endothelial Cells in PEGDA Scaffolds Encoded with Angiogenic Signals via Triple Helical Hybridization. Advanced functional materials. 2014 Jun;24(21):3213u201325.
• Wanjare M, Kusuma S, Gerecht S. Defining differences among perivascular cells derived from human pluripotent stem cells. Stem cell reports. 2014 May;2(5):561u201375.
• Shen Y-I, Abaci HE, Krupsi Y, Weng L-C, Burdick JA, Gerecht S. Hyaluronic acid hydrogel stiffness and oxygen tension affect cancer cell fate and endothelial sprouting. Biomaterials science. 2014 May;2(5):655u201365.
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• Abaci HE, Shen Y-I, Tan S, Gerecht S. Recapitulating physiological and pathological shear stress and oxygen to model vasculature in health and disease. Scientific reports. 2014 May;4:4951.
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• Kusuma S, Dickinson LE, Gerecht S. Cell-biomaterial interactions for blood vessel formation. In: Cardiac Regeneration and Repair: Biomaterials and Tissue Engineering. 2014. p. 350u201388.
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• Smulovitz C, Dickinson LE, Gerecht S. Micropatterned surfaces for the study of cancer and endothelial cell interactions with hyaluronic acid. Israel Journal of Chemistry. 2013 Dec 1;53(9u201310):710u20138.
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• Wang Y, Chou B-K, Dowey S, He C, Gerecht S, Cheng L. Scalable expansion of human induced pluripotent stem cells in the defined xeno-free E8 medium under adherent and suspension culture conditions. Stem cell research. 2013 Nov;11(3):1103u201316.
• Kusuma S, Gerecht S. Fast and furious: the mass and motion of stem cells. Biophysical journal. 2013 Aug;105(4):837u20138.
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• Kusuma S, Gerecht S. Recent progress in the use of induced pluripotent stem cells in vascular regeneration. Expert review of cardiovascular therapy. 2013 Jun;11(6):661u20133.
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• Wanjare M, Kuo F, Gerecht S. Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells. Cardiovascular research. 2013 Feb;97(2):321u201330.
• Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific reports. 2013 Jan;3:1449.
• Gerecht S. Spatially defined microenvironments to study tumor angiogensis. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2013.
• Shen T, Abaci E, Burdick JA, Gerecht S. Acrylated hyaluronic acid hydrogels to study cancer angiogenesis. In: Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future. 2013. p. 778.
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• Hielscher A, Qiu C, Porterfield J, Smith Q, Gerecht S. Hypoxia Affects the Structure of Breast Cancer Cell-Derived Matrix to Support Angiogenic Responses of Endothelial Cells. Journal of carcinogenesis & mutagenesis. 2013 Jan;Suppl 13:005.
• Barreto-Ortiz SF, Zhang S, Davenport M, Fradkin J, Ginn B, Mao H-Q, et al. A novel in vitro model for microvasculature reveals regulation of circumferential ECM organization by curvature. PloS one. 2013 Jan;8(11):e81061.
• Dar A, Gerecht S, Itskovitz-Eldor J. Human Vascular Progenitor Cells. In: Handbook of Stem Cells. 2013. p. 587u201394.
• Hielscher AC, Gerecht S. Engineering approaches for investigating tumor angiogenesis: exploiting the role of the extracellular matrix. Cancer research. 2012 Dec;72(23):6089u201396.
• Kusuma S, Zhao S, Gerecht S. The extracellular matrix is a novel attribute of endothelial progenitors and of hypoxic mature endothelial cells. FASEB journalu202f: official publication of the Federation of American Societies for Experimental Biology. 2012 Dec;26(12):4925u201336.
• Dickinson LE, Lu00fctgebaucks C, Lewis DM, Gerecht S. Patterning microscale extracellular matrices to study endothelial and cancer cell interactions in vitro. Lab on a chip. 2012 Nov;12(21):4244u20138.
• Hanjaya-Putra D, Wong KT, Hirotsu K, Khetan S, Burdick JA, Gerecht S. Spatial control of cell-mediated degradation to regulate vasculogenesis and angiogenesis in hyaluronan hydrogels. Biomaterials. 2012 Sep;33(26):6123u201331.
• Dickinson LE, Rand DR, Tsao J, Eberle W, Gerecht S. Endothelial cell responses to micropillar substrates of varying dimensions and stiffness. Journal of biomedical materials research Part A. 2012 Jun;100(6):1457u201366.
• Hielscher AC, Qiu C, Gerecht S. Breast cancer cell-derived matrix supports vascular morphogenesis. American journal of physiology Cell physiology. 2012 Apr;302(8):C1243u201356.
• Abaci HE, Devendra R, Soman R, Drazer G, Gerecht S. Microbioreactors to manipulate oxygen tension and shear stress in the microenvironment of vascular stem and progenitor cells. Biotechnology and applied biochemistry. 2012 Mar;59(2):97u2013105.
• Abaci HE, Devendra R, Smith Q, Gerecht S, Drazer G. Design and development of microbioreactors for long-term cell culture in controlled oxygen microenvironments. Biomedical microdevices. 2012 Feb;14(1):145u201352.
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• Sun G, Kusuma S, Gerecht S. Development of a biodegradable, temperature-sensitive dextran-based polymer as a cell-detaching substrate. Macromolecular bioscience. 2012 Jan;12(1):21u20138.
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• Yee D, Hanjaya-Putra D, Bose V, Luong E, Gerecht S. Hyaluronic Acid hydrogels support cord-like structures from endothelial colony-forming cells. Tissue engineering Part A. 2011 May;17(9u201310):1351u201361.
• Hanjaya-Putra D, Bose V, Shen Y-I, Yee J, Khetan S, Burdick JA, et al. Controllable and robust morphogenesis of functional vascular network assembly within synthetic environments. In: FASEB JOURNAL. 2011.
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• Wanjare M, Gerecht S, Kuo F. The derivation and maturation of vascular smooth muscle cells from human pluripotent stem cells. In: FASEB JOURNAL. 2011.
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• Dickinson LE, Gerecht S. Micropatterned surfaces to study hyaluronic acid interactions with cancer cells. Journal of visualized experimentsu202f: JoVE. 2010 Dec;(46):2413.
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• Dickinson LE, Moura ME, Gerecht S. Guiding endothelial progenitor cell tube formation using patterned fibronectin surfaces. Soft Matter. 2010 Oct 21;6(20):5109u201319.
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• Hanjaya-Putra D, Gerecht S. Preview. Mending the failing heart with a vascularized cardiac patch. Cell stem cell. 2009 Dec;5(6):575u20136.
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• Mei Y, Gerecht S, Taylor M, Urquhart AJ, Bogatyrev SR, Cho S-W, et al. Mapping the Interactions among Biomaterials, Adsorbed Proteins, and Human Embryonic Stem Cells. Advanced materials (Deerfield Beach, Fla). 2009 Jul;21(27):2781u20136.
• Sun G, Gerecht S. Vascular regeneration: engineering the stem cell microenvironment. Regenerative medicine. 2009 May;4(3):435u201347.
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• Gerecht S. Manipulating the microenvironment for vascular differentiation and regeneration. In: FASEB JOURNAL. 2009.
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• Gerecht S, Townsend SA, Pressler H, Zhu H, Nijst CLE, Bruggeman JP, et al. A porous photocurable elastomer for cell encapsulation and culture. Biomaterials. 2007 Nov;28(32):4826u201335.
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• Gerecht S, Burdick JA, Ferreira LS, Townsend SA, Langer R, Vunjak-Novakovic G. Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 2007 Jul;104(27):11298u2013303.
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• Gerecht S. Legal and ethical aspects of human embryonic stem cell research in Europe and Israel. In: IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL. 2005. p. 6A-6A.
• Shapira R, Zemel R, Gerecht S, Mor E, Ben-Ari Z, Zahavi I, et al. Transfusion-transmitted virus in liver-transplanted children. Transplantation proceedings. 2001 Sep;33(6):2957u20138.

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