Pranam D. Chatterjee

Assistant Professor of Biomedical Engineering

We develop diverse algorithmic modalities to discover, characterize, and engineer novel proteins for applications in genome editing, targeted protein modulation, and reproductive bioengineering.

Our long-term goals are two-fold:

1. Enable the de novo design of protein effectors for any biological purpose
2. Leverage our platform technologies to prolong and promote reproductive longevity and equality

Appointments and Affiliations

• Assistant Professor of Biomedical Engineering

Contact Information

• Email Address: pranam.chatterjee@duke.edu
• Websites:
  • programmable.bio

Education

• Ph.D. Massachusetts Institute of Technology, 2020

Research Interests

Integration of computational and experimental methodologies to design novel proteins for applications in genome editing, targeted protein modulation, and reproductive bioengineering

Courses Taught

• BME 390L: Special Topics with a Lab
• BME 493: Projects in Biomedical Engineering (GE)
• BME 494: Projects in Biomedical Engineering (GE)
• BME 590: Special Topics in Biomedical Engineering
• BME 791: Graduate Independent Study
• EGR 393: Research Projects in Engineering

In the News

• Pranam Chatterjee: Engineering the Reproductive System, One Protein at a Time | Duke Engineering News (Sept. 30, 2021)

Representative Publications

• Kobayashi, M; Kobayashi, M; Odajima, J; Shioda, K; Hwang, YS; Sasaki, K; Chatterjee, P; Kramme, C; Kohman, RE; Church, GM; Loehr, AR; Weiss, RS; Jüppner, H; Gell, JJ; Lau, CC; Shioda, T, Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers, Stem Cell Reports, vol 17 no. 3 (2022), pp. 507-521 [10.1016/j.stemcr.2022.01.012] [abs].
• Palepu, K; Ponnapati, M; Bhat, S; Tysinger, E; Stan, T; Brixi, G; Koseki, SRT; Chatterjee, P, Design of Peptide-Based Protein Degraders via Contrastive Deep Learning (2022) [10.1101/2022.05.23.493169] [abs].
• Kramme, C; Plesa, AM; Wang, HH; Wolf, B; Smela, MP; Guo, X; Kohman, RE; Chatterjee, P; Church, GM, MegaGate: A toxin-less gateway molecular cloning tool., Star Protocols, vol 2 no. 4 (2021) [10.1016/j.xpro.2021.100907] [abs].
• Kramme, C; Plesa, AM; Wang, HH; Wolf, B; Smela, MP; Guo, X; Kohman, RE; Chatterjee, P; Church, GM, An integrated pipeline for mammalian genetic screening., Cell Reports Methods, vol 1 no. 6 (2021) [10.1016/j.crmeth.2021.100082] [abs].
• Tripathy, S; Ponnapati, M; Jacobson, J; Chatterjee, P, Sub-Picomolar Detection of SARS-CoV-2 RBD via Computationally-Optimized Peptide Beacons (2021) [10.1101/2021.06.04.447114] [abs].