The Intestinal Stem Cell Niche in Homeostasis and Disease: A Shifting BMP Gradient

The McCarthy Lab investigates the cellular and tissue interactions that govern organ physiology, with a specific emphasis on the intestinal stem cell (ISC) niche. Utilizing a multipronged approach that integrates high-resolution confocal imaging, mouse genetics, and multi-omics sequencing, the lab seeks to decode how communication between intestinal fibroblasts and the epithelial compartment maintains homeostasis and how these pathways are altered in inflammatory bowel disease.