Dr Alastair Khodabukus, Ph.D.

Education

• Ph.D. University of Dundee (United Kingdom), 2011

Positions

• Assistant Research Professor in the Department of Biomedical Engineering

Publications

• Patsy M, Ge K, Khodabukus A, Bursac N. Development and modeling of cardiac autonomic innervation. Nature cardiovascular research. 2025 Dec;4(12):1598u2013615.
• Broer T, Tsintolas N, Hammond S, Helfer A, Lee J, Purkey K, et al. Human Myobundle Platform for Studying the Role of Notch Signaling in Satellite Cell Phenotype and Function. Advanced healthcare materials. 2025 May;14(12):e2404695.
• Broer T, Tsintolas N, Purkey K, Hammond S, DeLuca S, Wu T, et al. Engineered myovascular tissues for studies of endothelial/satellite cell interactions. Acta biomaterialia. 2024 Oct;188:65u201378.
• Khodabukus A, Prabhu NK, Roberts T, Buldo M, Detwiler A, Fralish ZD, et al. Bioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy. Adv Sci (Weinh). 2024 Aug;11(31):e2400188.
• Lee DE, McKay LK, Bareja A, Li Y, Khodabukus A, Bursac N, et al. Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling. Nat Commun. 2022 Dec 9;13(1):7613.
• Khodabukus A, Guyer T, Moore AC, Stevens MM, Guldberg RE, Bursac N. Translating musculoskeletal bioengineering into tissue regeneration therapies. Science translational medicine. 2022 Oct;14(666):eabn9074.
• Wang J, Broer T, Chavez T, Zhou CJ, Tran S, Xiang Y, et al. Myoblast deactivation within engineered human skeletal muscle creates a transcriptionally heterogeneous population of quiescent satellite-like cells. Biomaterials. 2022 May;284:121508.
• Vann CG, Zhang X, Khodabukus A, Orenduff MC, Chen Y-H, Corcoran DL, et al. Differential microRNA profiles of intramuscular and secreted extracellular vesicles in human tissue-engineered muscle. Front Physiol. 2022;13:937899.
• Wang J, Zhou CJ, Khodabukus A, Tran S, Han S-O, Carlson AL, et al. Three-dimensional tissue-engineered human skeletal muscle model of Pompe disease. Commun Biol. 2021 May 5;4(1):524.
• Khodabukus A. Tissue-Engineered Skeletal Muscle Models to Study Muscle Function, Plasticity, and Disease. Frontiers in Physiology. 2021 Feb 26;12.
• Fralish Z, Lotz EM, Chavez T, Khodabukus A, Bursac N. Neuromuscular Development and Disease: Learning From in vitro and in vivo Models. Frontiers in cell and developmental biology. 2021 Jan;9:764732.
• Kondash ME, Ananthakumar A, Khodabukus A, Bursac N, Truskey GA. Glucose Uptake and Insulin Response in Tissue-engineered Human Skeletal Muscle. Tissue engineering and regenerative medicine. 2020 Dec;17(6):801u201313.
• Khodabukus A, Kaza A, Wang J, Prabhu N, Goldstein R, Vaidya VS, et al. Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers. Toxicological sciencesu202f: an official journal of the Society of Toxicology. 2020 Jul;176(1):124u201336.
• Broer T, Khodabukus A, Bursac N. Can we mimic skeletal muscles for novel drug discovery? Expert opinion on drug discovery. 2020 Jun;15(6):643u20135.
• Wang J, Khodabukus A, Rao L, Vandusen K, Abutaleb N, Bursac N. Engineered skeletal muscles for disease modeling and drug discovery. Biomaterials. 2019 Nov;221:119416.
• Khodabukus A, Madden L, Prabhu NK, Koves TR, Jackman CP, Muoio DM, et al. Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle. Biomaterials. 2019 Apr;198:259u201369.
• Khodabukus A, Prabhu N, Wang J, Bursac N. In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease. Advanced healthcare materials. 2018 Aug;7(15):e1701498.
• Rao L, Qian Y, Khodabukus A, Ribar T, Bursac N. Engineering human pluripotent stem cells into a functional skeletal muscle tissue. Nature communications. 2018 Jan;9(1):126.
• Shadrin IY, Khodabukus A, Bursac N. Striated muscle function, regeneration, and repair. Cellular and molecular life sciencesu202f: CMLS. 2016 Nov;73(22):4175u2013202.
• Khodabukus A, Baar K. Factors That Affect Tissue-Engineered Skeletal Muscle Function and Physiology. Cells, tissues, organs. 2016 Jan;202(3u20134):159u201368.
• Khodabukus A, Baehr LM, Bodine SC, Baar K. Role of contraction duration in inducing fast-to-slow contractile and metabolic protein and functional changes in engineered muscle. Journal of cellular physiology. 2015 Oct;230(10):2489u201397.
• Khodabukus A, Baar K. Contractile and metabolic properties of engineered skeletal muscle derived from slow and fast phenotype mouse muscle. Journal of cellular physiology. 2015 Aug;230(8):1750u20137.
• Khodabukus A, Baar K. Glucose concentration and streptomycin alter in vitro muscle function and metabolism. Journal of cellular physiology. 2015 Jun;230(6):1226u201334.
• Khodabukus A, Baar K. Streptomycin decreases the functional shift to a slow phenotype induced by electrical stimulation in engineered muscle. Tissue engineering Part A. 2015 Mar;21(5u20136):1003u201312.
• Khodabukus A, Baar K. The effect of serum origin on tissue engineered skeletal muscle function. Journal of cellular biochemistry. 2014 Dec;115(12):2198u2013207.
• Khodabukus A, Baar K. Defined electrical stimulation emphasizing excitability for the development and testing of engineered skeletal muscle. Tissue engineering Part C, Methods. 2012 May;18(5):349u201357.
• Khodabukus A, Baar K. Regulating fibrinolysis to engineer skeletal muscle from the C2C12 cell line. Tissue engineering Part C, Methods. 2009 Sep;15(3):501u201311.
• Khodabukus A, Paxton JZ, Donnelly K, Baar K. Engineered muscle: a tool for studying muscle physiology and function. Exercise and sport sciences reviews. 2007 Oct;35(4):186u201391.