Dmitry Velmeshev

Bio

The goal of the Velmeshev lab is to understand normal human brain development and neurodevelopmental diseases at the single cell level.u200b We are particularly interested in gaining a holistic view of how genetic programs instruct neural progenitors that give rise to the diverse cell types of the brain and guide formation of neuronal circuits, and how these processes are affected in brain disorders, such as autism.

Education

• Ph.D. University of Miami, 2016

Positions

• Assistant Professor of Neurobiology
• Assistant Professor of Biomedical Engineering

Courses Taught

• NEUROSCI 494: Research Independent Study 2
• NEUROSCI 493: Research Independent Study 1
• NEUROBIO 790S: Student Seminar (Topics)
• NEUROBIO 735: Quantitative Approaches in Neurobiology
• CMB 710F: Cell & Molecular Biology Module VI
• CMB 710E: Cell & Molecular Biology Module V

Publications

• Gao Y, Shonai D, Trn M, Zhao J, Soderblom EJ, Garcia-Moreno SA, et al. Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions. Nat Commun. 2024 Aug 9;15(1):6801.
• Yuan Y, Li H, Sreeram K, Malankhanova T, Boddu R, Strader S, et al. Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation. Mol Neurodegener. 2024 Jun 11;19(1):47.
• Velmeshev D, Perez Y, Yan Z, Valencia JE, Castaneda-Castellanos DR, Wang L, et al. Single-cell analysis of prenatal and postnatal human cortical development. Science. 2023 Oct 13;382(6667):eadf0834.
• Marsan E, Velmeshev D, Ramsey A, Patel RK, Zhang J, Koontz M, et al. Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations. J Clin Invest. 2023 Mar 15;133(6).
• Trobisch T, Zulji A, Stevens NA, Schwarz S, Wischnewski S, Öztürk M, et al. Cross-regional homeostatic and reactive glial signatures in multiple sclerosis. Acta Neuropathol. 2022 Nov;144(5):987–1003.
• Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, et al. Tropism of SARS-CoV-2 for human cortical astrocytes. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2122236119.
• Gao Y, Trn M, Shonai D, Zhao J, Soderblom E, Garcia-Moreno A, et al. Proximity Analysis of Native Proteomes Reveals Interactomes Predictive of Phenotypic Modifiers of Autism and Related Neurodevelopmental Conditions. bioRxiv. 2022.
• Velmeshev D, Perez Y, Yan Z, Valencia J, Castaneda-Castellanos D, Wang L, et al. Single-cell analysis of prenatal and postnatal human cortical development. bioRxiv. 2022.
• Velmeshev D, Chavali M, Nowakowski T, Bhade M, Mayer S, Goyal N, et al. Molecular diversity and lineage commitment of human interneuron progenitors. bioRxiv. 2021.
• Zhang J, Velmeshev D, Hashimoto K, Huang Y-H, Hofmann JW, Shi X, et al. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 Dec;588(7838):459–65.
• Huang W, Bhaduri A, Velmeshev D, Wang S, Wang L, Rottkamp CA, et al. Origins and Proliferative States of Human Oligodendrocyte Precursor Cells. Cell. 2020 Aug 6;182(3):594-608.e11.
• Herrero MJ, Velmeshev D, Hernandez-Pineda D, Sethi S, Sorrells S, Banerjee P, et al. Identification of amygdala-expressed genes associated with autism spectrum disorder. Mol Autism. 2020 May 27;11(1):39.
• Velmeshev D, Magistri M, Mazza EMC, Lally P, Khoury N, D’Elia ER, et al. Cell-Type-Specific Analysis of Molecular Pathology in Autism Identifies Common Genes and Pathways Affected Across Neocortical Regions. Mol Neurobiol. 2020 May;57(5):2279–89.
• Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, et al. Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. Cell Stem Cell. 2020 Jan 2;26(1):48-63.e6.
• Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, et al. Neuronal vulnerability and multilineage diversity in multiple sclerosis. Nature. 2019 Sep;573(7772):75–82.
• Sorrells SF, Paredes MF, Velmeshev D, Herranz-Pérez V, Sandoval K, Mayer S, et al. Immature excitatory neurons develop during adolescence in the human amygdala. Nat Commun. 2019 Jun 21;10(1):2748.
• Velmeshev D, Schirmer L, Jung D, Haeussler M, Perez Y, Mayer S, et al. Single-cell genomics identifies cell type-specific molecular changes in autism. Science. 2019 May 17;364(6441):685–9.
• Mayer S, Chen J, Velmeshev D, Mayer A, Eze UC, Bhaduri A, et al. Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex. Neuron. 2019 Apr 3;102(1):143-158.e7.
• Nowakowski TJ, Bhaduri A, Pollen AA, Alvarado B, Mostajo-Radji MA, Di Lullo E, et al. Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex. Science. 2017 Dec 8;358(6368):1318–23.
• Sartor GC, Powell SK, Velmeshev D, Lin DY, Magistri M, Wiedner HJ, et al. Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens. Mol Cell Neurosci. 2017 Dec;85:183–9.
• Grieco SF, Velmeshev D, Magistri M, Eldar-Finkelman H, Faghihi MA, Jope RS, et al. Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3. World J Biol Psychiatry. 2017 Sep;18(6):445–56.
• Chang K-C, Hertz J, Zhang X, Jin X-L, Shaw P, Derosa BA, et al. Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development. J Neurosci. 2017 May 10;37(19):4967–81.
• Pardo M, Cheng Y, Velmeshev D, Magistri M, Eldar-Finkelman H, Martinez A, et al. Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice. JCI Insight. 2017 Mar 23;2(6):e91782.
• Pastori C, Velmeshev D, Peschansky VJ. Deep-RACE: Comprehensive Search for Novel ncRNAs Associated to a Specific Locus. In 2017. p. 129–43.
• Magistri M, Velmeshev D. Identification of Long Noncoding RNAs Associated to Human Disease Susceptibility. In 2017. p. 197–208.
• Magistri M, Khoury N, Mazza EMC, Velmeshev D, Lee JK, Bicciato S, et al. A comparative transcriptomic analysis of astrocytes differentiation from human neural progenitor cells. Eur J Neurosci. 2016 Nov;44(10):2858–70.
• Peschansky VJ, Pastori C, Zeier Z, Wentzel K, Velmeshev D, Magistri M, et al. The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans. Mol Cell Neurosci. 2016 Jul;74:49–57.
• Velmeshev D, Lally P, Magistri M, Faghihi MA. CANEapp: a user-friendly application for automated next generation transcriptomic data analysis. BMC Genomics. 2016 Jan 13;17:49.
• Magistri M, Velmeshev D, Makhmutova M, Patel P, Sartor GC, Volmar C-H, et al. The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease. Curr Alzheimer Res. 2016;13(9):985–95.
• Bobkova NV, Evgen’ev M, Garbuz DG, Kulikov AM, Morozov A, Samokhin A, et al. Exogenous Hsp70 delays senescence and improves cognitive function in aging mice. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):16006–11.
• Trakhtenberg EF, Morkin MI, Patel KH, Fernandez SG, Sang A, Shaw P, et al. The N-terminal Set-β Protein Isoform Induces Neuronal Death. J Biol Chem. 2015 May 22;290(21):13417–26.
• Magistri M, Velmeshev D, Makhmutova M, Faghihi MA. Transcriptomics Profiling of Alzheimer's Disease Reveal Neurovascular Defects, Altered Amyloid-β Homeostasis, and Deregulated Expression of Long Noncoding RNAs. J Alzheimers Dis. 2015;48(3):647–65.
• Peschansky VJ, Pastori C, Zeier Z, Motti D, Wentzel K, Velmeshev D, et al. Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells. Front Genet. 2015;6:263.
• Fatemi RP, Velmeshev D, Faghihi MA. De-repressing LncRNA-Targeted Genes to Upregulate Gene Expression: Focus on Small Molecule Therapeutics. Mol Ther Nucleic Acids. 2014 Nov 18;3(11):e196.
• Slepak V, Pronin A, Levay K, Velmeshev D, Faghihi M, Shestopalov V. Expression of olfactory GPCR signaling genes in the eye (662.15). The FASEB Journal. 2014 Apr;28(S1).
• Pronin A, Levay K, Velmeshev D, Faghihi M, Shestopalov VI, Slepak VZ. Expression of olfactory signaling genes in the eye. PLoS One. 2014;9(4):e96435.
• Velmeshev D, Magistri M, Faghihi MA. Expression of non-protein-coding antisense RNAs in genomic regions related to autism spectrum disorders. Mol Autism. 2013 Sep 4;4(1):32.
• Park J-H, Glass Z, Sayed K, Michurina TV, Lazutkin A, Mineyeva O, et al. Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain. Eur J Neurosci. 2013 Jun;37(12):1987–93.