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Xiling Shen

Xiling Shen

Hawkins Family Associate Professor

The Shen lab uses systems biology to study spatiotemporal controls of multicellular systems, and how their subversion lead to diseases. Ongoing projects include colon cancer, normal and cancer stem cells, non-coding RNA, enteric nervious system, and tuberculosis.

Appointments and Affiliations

  • Hawkins Family Associate Professor
  • Associate Professor in the Department of Biomedical Engineering
  • Associate Professor in the Department of Electrical and Computer Engineering
  • Associate Professor in Molecular Genetics and Microbiology
  • Member of the Duke Cancer Institute
  • Affiliate of the Regeneration Next Initiative

Contact Information

  • Office Location: 2167 Ciemas, 101 Science Drive, Box 3382, Durham, NC 27708
  • Office Phone: (919) 681-9184
  • Email Address:
  • Websites:


  • Ph.D. Stanford University, 2008
  • M.Sc. Stanford University, 2001
  • B.Sc. Stanford University, 2001

Research Interests

Dr. Shen's research integrates systems biology and implantable devices to study non-coding RNA, colon cancer, stem cells, and the enteric nervous system. His multidisciplinary approach provides a new window for developing novel therapeutics against heterogeneous diseases such as cancer.

Courses Taught

  • BME 260L: Modeling Cellular and Molecular Systems
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 590L: Special Topics with Lab
  • EGR 393: Research Projects in Engineering

In the News

Representative Publications

  • Bu, P; Chen, K-Y; Xiang, K; Johnson, C; Crown, SB; Rakhilin, N; Ai, Y; Wang, L; Xi, R; Astapova, I; Han, Y; Li, J; Barth, BB; Lu, M; Gao, Z; Mines, R; Zhang, L; Herman, M; Hsu, D; Zhang, G-F; Shen, X, Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis., Cell Metabolism, vol 27 no. 6 (2018), pp. 1249-1262.e4 [10.1016/j.cmet.2018.04.003] [abs].
  • Rakhilin, N; Barth, B; Choi, J; Muñoz, NL; Kulkarni, S; Jones, JS; Small, DM; Cheng, Y-T; Cao, Y; LaVinka, C; Kan, E; Dong, X; Spencer, M; Pasricha, P; Nishimura, N; Shen, X, Simultaneous optical and electrical in vivo analysis of the enteric nervous system., Nature Communications, vol 7 (2016) [10.1038/ncomms11800] [abs].
  • Bu, P; Wang, L; Chen, K-Y; Srinivasan, T; Murthy, PKL; Tung, K-L; Varanko, AK; Chen, HJ; Ai, Y; King, S; Lipkin, SM; Shen, X, A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer., Cell Stem Cell, vol 18 no. 2 (2016), pp. 189-202 [10.1016/j.stem.2016.01.006] [abs].
  • Chen, HJ; Sun, J; Huang, Z; Hou, H; Arcilla, M; Rakhilin, N; Joe, DJ; Choi, J; Gadamsetty, P; Milsom, J; Nandakumar, G; Longman, R; Zhou, XK; Edwards, R; Chen, J; Chen, KY; Bu, P; Wang, L; Xu, Y; Munroe, R; Abratte, C; Miller, AD; Gümüş, ZH; Shuler, M; Nishimura, N; Edelmann, W; Shen, X; Lipkin, SM, Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting., Nature Biotechnology, vol 33 no. 6 (2015), pp. 656-660 [10.1038/nbt.3239] [abs].
  • Bu, P; Chen, K-Y; Chen, JH; Wang, L; Walters, J; Shin, YJ; Goerger, JP; Sun, J; Witherspoon, M; Rakhilin, N; Li, J; Yang, H; Milsom, J; Lee, S; Zipfel, W; Jin, MM; Gümüş, ZH; Lipkin, SM; Shen, X, A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells., Cell Stem Cell, vol 12 no. 5 (2013), pp. 602-615 [10.1016/j.stem.2013.03.002] [abs].