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Warren M. Grill

Warren M. Grill

Professor of Biomedical Engineering

Our research employs engineering approaches to understand and control neural function. We work on fundamental questions and applied development in electrical stimulation of the nervous system to restore function to individuals with neurological impairment or injury.

Current projects include:
• understanding the mechanisms of and developing advanced approaches to deep brain stimulation to treat movement disorders,
• developing novel approaches to peripheral nerve electrical stimulation for restoration of bladder function, 
• understanding the mechanisms of and developing advanced approaches to spinal cord stimulation to treat chronic pain,
• understanding and controlling the cellular effects of transcranial magnetic stimulation, and
• design of novel electrodes and waveforms for selective stimulation of the nervous system.

Appointments and Affiliations

  • Professor of Biomedical Engineering
  • Edmund T. Pratt, Jr. School Professor of Biomedical Engineering
  • Bass Fellow
  • Associate of the Duke Initiative for Science & Society
  • Professor in Neurobiology
  • Professor in Neurosurgery
  • Core Faculty in Innovation & Entrepreneurship
  • Professor in the Department of Electrical and Computer Engineering
  • Faculty Network Member of the Duke Institute for Brain Sciences

Contact Information

Education

  • Ph.D. Case Western Reserve University, 1995
  • M.S. Case Western Reserve University, 1992
  • B.S. Boston University, 1989

Research Interests

Neural engineering and neural prostheses and include design and testing of electrodes and stimulation techniques, the electrical properties of tissues and cells, and computational neuroscience with applications in restoration of bladder function, treatment of movement disorders with deep brain stimulation, and treatment of chronic pain.

Awards, Honors, and Distinctions

  • Capers & Marion McDonald Award for Excellence in Teaching and Research. Pratt School of Engineering. 2018
  • Javits Neuroscience Investigator Award. NIH-NINDS . 2015
  • Scholar / Teacher of the Year Award. Duke University. 2014
  • Outstanding Postdoc Mentor. Duke University. 2013
  • Fellow. Biomedical Engineering Society. 2011
  • Fellow. American Institute for Medical and Biological Engineering. 2007

Courses Taught

  • BME 301L: Bioelectricity (AC or GE)
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 504: Fundamentals of Electrical Stimulation of the Nervous System (GE, EL)
  • BME 515: Neural Prosthetic Systems (GE, EL, IM)
  • BME 790L: Advanced Topics with the Lab for Graduate Students in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • ECE 899: Special Readings in Electrical Engineering
  • NEUROSCI 301L: Bioelectricity (AC or GE)
  • NEUROSCI 504: Fundamentals of Electrical Stimulation of the Nervous System (GE, EL)
  • NEUROSCI 515: Neural Prosthetic Systems (GE, EL, IM)

In the News

Representative Publications

  • Aberra, AS; Peterchev, AV; Grill, WM, Biophysically realistic neuron models for simulation of cortical stimulation., Journal of Neural Engineering, vol 15 no. 6 (2018) [10.1088/1741-2552/aadbb1] [abs].
  • Gonzalez, EJ; Grill, WM, Sensory pudendal nerve stimulation increases bladder capacity through sympathetic mechanisms in cyclophosphamide-induced cystitis rats., Neurourology and Urodynamics (2018) [10.1002/nau.23860] [abs].
  • Huffman, WJ; Subramaniyan, S; Rodriguiz, RM; Wetsel, WC; Grill, WM; Terrando, N, Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice., Brain Stimulation (2018) [10.1016/j.brs.2018.10.005] [abs].
  • Yi, G; Grill, WM, Frequency-dependent antidromic activation in thalamocortical relay neurons: effects of synaptic inputs., Journal of Neural Engineering, vol 15 no. 5 (2018) [10.1088/1741-2552/aacbff] [abs].
  • Jovanov, I; Naumann, M; Kumaravelu, K; Grill, WM; Pajic, M, Platform for Model-Based Design and Testing for Deep Brain Stimulation, Proceedings 9th Acm/Ieee International Conference on Cyber Physical Systems, Iccps 2018 (2018), pp. 263-274 [10.1109/ICCPS.2018.00033] [abs].

Selected Activities

  • Consultant, Neurological Devices Panel of the Medical Devices Advisory Committee,Center for Devices and Radiological Health,
  • Editorial Board, Journal of Neural Engineering,
  • Editorial Board, Brain Stimulation,