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Mikhail Albertovich Nikiforov

Nikiforov

Professor of Pathology

Appointments and Affiliations

  • Professor of Pathology
  • Professor in the Department of Biomedical Engineering
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: 40 Duke Medicine Circle, Durham, NC 27710
  • Email Address: mikhail.nikiforov@duke.edu

Education

  • Ph.D. University of Illinois, 1997
  • M.S. Lomonosov Moscow State University (Russia), 1992
  • B.S. Lomonosov Moscow State University (Russia), 1992

Research Interests

Identification and therapeutic exploitation of mechanisms underlying the deregulated transcription programs and metabolism in cancer cells. We pursue these objectives by integrating intracellular imaging, organoid technology, animal modeling, transcriptomics, proteomics and metabolomics.

Courses Taught

  • BME 570L: Introduction to Biomolecular Engineering (GE, BB, MC)

Representative Publications

  • Wolff, DW; Bianchi-Smiraglia, A; Nikiforov, MA, Compartmentalization and regulation of GTP in control of cellular phenotypes., Trends Mol Med, vol 28 no. 9 (2022), pp. 758-769 [10.1016/j.molmed.2022.05.012] [abs].
  • Wolff, DW; Deng, Z; Bianchi-Smiraglia, A; Foley, CE; Han, Z; Wang, X; Shen, S; Rosenberg, MM; Moparthy, S; Yun, DH; Chen, J; Baker, BK; Roll, MV; Magiera, AJ; Li, J; Hurley, E; Feltri, ML; Cox, AO; Lee, J; Furdui, CM; Liu, L; Bshara, W; LaConte, LEW; Kandel, ES; Pasquale, EB; Qu, J; Hedstrom, L; Nikiforov, MA, Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4., Cell Chem Biol, vol 29 no. 6 (2022), pp. 970-984.e6 [10.1016/j.chembiol.2022.01.007] [abs].
  • Bianchi-Smiraglia, A; Nikiforov, MA, Assessment of Intracellular GTP Levels Using Genetically Encoded Fluorescent Sensors., vol 2394 (2022), pp. 163-169 [10.1007/978-1-0716-1811-0_10] [abs].
  • Bianchi-Smiraglia, A; Wolff, DW; Marston, DJ; Deng, Z; Han, Z; Moparthy, S; Wombacher, RM; Mussell, AL; Shen, S; Chen, J; Yun, D-H; O'Brien Cox, A; Furdui, CM; Hurley, E; Feltri, ML; Qu, J; Hollis, T; Kengne, JBN; Fongang, B; Sousa, RJ; Kandel, ME; Kandel, ES; Hahn, KM; Nikiforov, MA, Author Correction: Regulation of local GTP availability controls RAC1 activity and cell invasion., Nature Communications, vol 12 no. 1 (2021) [10.1038/s41467-021-26665-2] [abs].
  • Bianchi-Smiraglia, A; Wolff, DW; Marston, DJ; Deng, Z; Han, Z; Moparthy, S; Wombacher, RM; Mussell, AL; Shen, S; Chen, J; Yun, D-H; O'Brien Cox, A; Furdui, CM; Hurley, E; Feltri, ML; Qu, J; Hollis, T; Kengne, JBN; Fongang, B; Sousa, RJ; Kandel, ME; Kandel, ES; Hahn, KM; Nikiforov, MA, Regulation of local GTP availability controls RAC1 activity and cell invasion., Nature Communications, vol 12 no. 1 (2021) [10.1038/s41467-021-26324-6] [abs].