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Michael D Lynch


Assistant Professor in the Department of Biomedical Engineering

Appointments and Affiliations

  • Assistant Professor in the Department of Biomedical Engineering
  • Faculty Fellow in The Energy Initiative
  • Associate of the Duke Initiative for Science & Society

Contact Information


  • M.D. University of Colorado School of Medicine, 2007
  • Ph.D. University of Colorado - Boulder, 2005

Research Interests

Focused on genetically engineering microbes to shut off their growth circuits and turn on new pathways to produce different compounds—improving production of biofuels, pharmacological molecules and industrial chemicals.

Courses Taught

  • BME 490L: Special Topics in Biomedical Engineering Design (DR)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 590D: Special Topics with Discussion
  • BME 590L: Special Topics with Lab
  • BME 703S: Engineering Management Seminar for Master of Science Students
  • BME 790L: Advanced Topics with the Lab for Graduate Students in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study
  • EGR 393: Research Projects in Engineering
  • ISS 293: ISS Research Independent Study
  • ISS 391: Bass Connections in Information Science and Culture: Independent Study Project
  • ISS 795: Connections in Information, Society and Culture: Project

In the News

Representative Publications

  • Menacho-Melgar, R; Moreb, EA; Efromson, JP; Yang, T; Hennigan, JN; Wang, R; Lynch, MD, Improved two-stage protein expression and purification via autoinduction of both autolysis and auto DNA/RNA hydrolysis conferred by phage lysozyme and DNA/RNA endonuclease., Biotechnology and Bioengineering, vol 117 no. 9 (2020), pp. 2852-2860 [10.1002/bit.27444] [abs].
  • Decker, JS; Menacho-Melgar, R; Lynch, MD, Low-Cost, Large-Scale Production of the Anti-viral Lectin Griffithsin, Frontiers in Bioengineering and Biotechnology, vol 8 (2020) [10.3389/fbioe.2020.01020] [abs].
  • Li, S; Moreb, E; Ye, Z; Hennigan, J; Castellanos, DB; Yang, T; Lynch, M, Dynamic control over feedback regulatory mechanisms improves NADPH fluxes and xylitol biosynthesis in engineered E. coli (2020) [10.1101/2020.07.27.222588] [abs].
  • Ye, Z; Lebeau, J; Moreb, E; Menacho-Melgar, R; Lynch, M, The E. coli Cas1/2 endonuclease complex reduces CRISPR/Cascade guide array stability (2020) [10.1101/2020.07.27.223214] [abs].
  • Li, S; Ye, Z; Lebeau, J; Moreb, E; Lynch, M, Dynamic control over feedback regulation identifies pyruvate-ferredoxin oxidoreductase as a central metabolic enzyme in stationary phase E. coli (2020) [10.1101/2020.07.26.219949] [abs].