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Scientists form alliance to develop nanotoxicology protocols
A team of materials scientists and toxicologists announced the formation of a new international research alliance to establish protocols for reproducible toxicological testing of nanomaterials in both cultured cells and animals.
Pratt’s Mark Wiesner, James L. Meriam Professor of Civil and Environmental Engineering is part of this research effort.
The International Alliance for NanoEHS Harmonization (IANH) was unveiled Sept. 9 at Nanotox 2008, one of the world's largest biennial nanotoxicological research meetings.
“When this team of scientists from Europe, the U.S., and Japan are able to get the same results for interactions of nanomaterials with biological organisms, then science and society can have higher confidence in the safety of these materials,” said Kenneth Dawson, of University College Dublin and current chair of the IANH team.
Nanotechnology provides the opportunity for enabling new products that could meet a wide range of societal needs, but concerns over potential environmental, health and safety impacts of these materials may limit their adoption. Multiple organizations, including the Organization for Economic Co-operation and Development (OECD) and the International Nanotechnology Conference for Communication and Cooperation (INC), have highlighted the importance of international collaboration to accelerate understanding of nanotechnology implications for society. IANH, was established by leading materials and toxicological researchers to address this need.
Although Andrew Maynard, chief scientist at the Project on Emerging Nanotechnologies, Woodrow Wilson International Center for Scholars in Washington, DC, is not a member of this alliance, he sees the need for this effort.
"This initiative is a major step toward ensuring hazard evaluations of emerging nanomaterials that are both relevant and reproducible," he said.
In addition to Wiesner, the IANH team includes the following researchers:
- Wolfgang Kreyling of Helmholtz Institute, Germany
- Kenneth Dawson, University College Dublin
- Gaku Ichihara, Nagoya University, Japan
- Kun’ichi Miyazawa, National Institute for Materials Science, Japan
- Harald Krug, Swiss Federal Laboratories for Materials Testing and Research
- Vicki Stone, Napier University, United Kingdom
- Vince Castranova, Mark Hoover, Dale Porter, and Aleksandr Stefaniak, National Institute for Occupational Safety and Health at the Centers for Disease Control and Prevention
- Vicki Colvin, Rice University
- Fred Klaessig and Andre’ Nel, University of California at Los Angeles
- Gunter Oberdorster and Alison Elder, University of Rochester
Others collaborating with this alliance include from the European Union Joint Research Centre: Gert Roebben and Hendrik Emons of the Institute for Reference Materials and Measurements. From the U.S. Vince Hackley of the National Institute of Standards and Technology; and Scott McNeil of the Nanotechnology Characterization Laboratory at the National Cancer Institute are also collaborating with the alliance.
Previous studies have identified key gaps in scientific knowledge regarding the biological interactions with nanoparticles and subsequent toxicological responses. Progress in resolving these issues is limited by the lack of testing protocols that enable reproducible assessment of the biological interactions of nanoparticles with cells and animals, and the lack of correlations between interactions observed in cells and in animals.
IANH is being formed to establish testing protocols that enable reproducible toxicological testing of nanomaterials at the cell and animal levels and to start developing correlations between these two systems.
IANH members have agreed to develop specific tools and testing protocols and to perform a set of round robin experiments to lay the foundation for reproducible testing of nanomaterial biological interactions and toxicology. The alliance will establish protocols that can be shared with other researchers and foster experiments to evaluate correlations between in vitro testing and toxicological interactions in mammals and aquatic animals. These reproducible nano-biological testing protocols should enable better assessment of potential biological interactions of nanomaterials and improve correlations between in vitro testing and outcomes in animals, humans and the environment.
This effort was encouraged by the National Science Foundation, National Institutes of Health, National Institute for Occupational Safety and Health, National Institute of Standards and Technology, Seventh Framework Programme of the European Community for research, technological development and demonstration activities, and Japanese National Institute for Materials Science.
For more information: http://www.nanoehsalliance.org