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Maccarini Receives 2013 Chandran Award

Paolo Maccarini, Ph.D.

Paolo Maccarini, Ph.D., received the 2013 Chandran Discretionary Research Award for his proposal entitled, "A Novel MR-Based Noninvasive Method to Safely Modulate the Opening of Blood-Brain-Barrier to Enhance Drug Delivery into Brain Tumors and Target Neurological Diseases." Maccarini is an Assistant Research Professor in the Duke Department of Biomedical Engineering.

The proposed multidisciplinary collaboration aims to demonstrate a novel noninvasive method to temporarily open the blood-brain-barrier in a safe and reversible manner. The method responds to an unmet clinical need of a low cost and safe solution to enhance the delivery of therapeutic or imaging agents into brain, including targeting of tumors or neurodegenerative diseases such as Parkinson’s and Alzheimer's.

The proposed non-invasive magnetic resonance technique to temporarily and reversibly open the this barrier could have far-reaching impact.

About the Award

Beverly A. and Clarence J. Chandran established this award to fund Duke University research related to early detection of brain tumors. The major goals of this initiative are to design better methods of tumor detection, tumor characterization, and measurement of effects of tumor therapy in the brain or spinal cord.