VFF: Visualizing the food-sensing biosensors of our gut

Sep 12

Friday, September 12, 2014

12:00 pm - 1:00 pm


Diego V Bohórquez · Duke Medical Center

Our brain is fed with sensory information from food in our gut through specialized biosensors called enteroendocrine cells. For a long time these cells have been assumed to communicate with nerves indirectly through hormones. The primary reason is that they are difficult to identify and a complete description of their anatomy is lacking. Here we develop a method to correlate confocal microscopy with serial block face scanning electron microscopy and document the entire ultrastructure of a specific enteroendocrine cell. Using manual segmentation and volume rendering, we uncovered in enteroendocrine cells a prominent neuropod ¿ the missing link to nerves carrying sensory information to the brain.


Zoss, Angela

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