Brenton Hoffman, Assistant Professor, Dept. of Biomedical Engineering
Brenton Hoffman joined Duke as an assistant professor of Biomedical Engineering on January 1, 2012. He received a BS in Chemical Engineering from Lehigh University and a PhD in Chemical and Biomolecular Engineering from the University of Pennsylvania. His doctoral research, conducted under the supervision of Prof. John Crocker, utilized principles and techniques from soft matter physics to study the molecular processes mediating the dynamic nature cellular mechanical properties. After receiving his PhD in 2007, he joined the Cardiovascular Research Center at the University of Virginia as a Post-doctoral researcher in the laboratory of Prof. Martin Schwartz. Here he developed a genetically encoded, calibrated molecular tension sensor capable of visualizing molecular force across specific proteins in living cells. He plans to combine these research areas to determine the mechanisms cells utilize to sense and respond to the mechanical nature of their microenviroment. Understanding these processes on the molecular level will aid in the development of novel tissue engineering constructs for use in regenerative medicine as well as help develop new treatments for mechanosensitive diseases, such as atherosclerosis and cancer. For more information about Brenton, visit his faculty webpage.