MEMS Seminar: Rapid 3D Printing of Functional Scaffolds and Precision Tissue Models

Oct 31

Monday, October 31, 2016

3:00 pm - 4:00 pm
Fitzpatrick Center Schiciano Auditorium Side A


Professor Shaochen Chen, UCSD

The goal of our laboratory is to develop micro- and nano-scale bioprinting and 3D printing techniques to create 3D designer scaffolds for tissue engineering and regenerative medicine. In this talk, I will present my laboratory's recent research efforts in rapid continuous projection 3D bioprinting to create 3D scaffolds using a variety of biomaterials. These 3D biomaterials are functionalized with precise control of micro-architecture, mechanical (e.g. stiffness and Poisson's ratio), chemical, and biological properties. Design, fabrication, and experimental results will be discussed. Such functional biomaterials allow us to investigate cell-microenvironment interactions at nano- and micro-scales in response to integrated physical and chemical stimuli1. From these fundamental studies we can create both in vitro and in vivo tissue models for precision tissue engineering and regenerative medicine2. 1. M. Gou, X. Qu, W. Zhu, M. Xiang, J. Yang, K. Zhang, Y. Wei, and S.C. Chen, Bio-inspired Detoxification using 3D-printed Hydrogel Nanocomposites", Nature Communications, 5: 3774, 20142. X. Ma, X. Qu, W. Zhu, Y.-S. Li, S. Yuan, H. Zhang, J. Liu, P. Wang, C. S. Lai, F. Zanella, G.-S. Feng, F. Sheikh, S. Chien, S.C. Chen, "A Deterministically Patterned Biomimetic Human iPSC-derived Hepatic Model via Rapid 3D Bioprinting", Proceedings of the National Academy of Sciences (PNAS), Vol. 113 (no. 8), pp. 2206-2211, 2016. Lunch will be served from 11:30 am - 12:00 noon.

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Siler, Katherine