BioE Seminar: Synthetic Biology and Cancer Immunotherapy
Thursday, October 26, 2017
12:00 pm - 1:00 pm
Fitzpatrick Center Schiciano Auditorium Side B
Wilson Wong, Assistant Professor, Department of Biomedical Engineering, Boston University
Abstract: Genetically engineered cells hold great promise for improving therapeutics, diagnostics, animal models, and industrial biotechnological processes. Here I will describe our universal chimeric antigen receptor system (CAR) for multiplexed and logic control of T cell responses. This Universal CAR system could provide tools for managing the toxicity associated with T cell cancer immunotherapy. I will also discuss our Boolean and Arithmetic through DNA Excision (BLADE) system for designing genetic circuits with multiple inputs and outputs in mammalian cells. BLADE enables execution of sophisticated cellular computations, with applications in cell and tissue engineering. Together, the Universal CAR and BLADE systems highlight an expanding toolset for flexibly controlling mammalian cell functions.