BioE Seminar Series
Thursday, October 13, 2016
4:30 pm - 5:30 pm
Fitzpatrick Center Schiciano Auditorium Side B
Manu Platt, Ph.D.
Manu Platt, Ph.D.Associate Professor, Georgia Institute of Technology & Emory UniversityTitle: Quantitative Dissection of Proteolytic Networks Governing Tissue Remodeling in Health and DiseaseAbstract: Patient-to-patient variability in disease progression continues to complicate clinical decisions in diagnosis and treatment. We focus on individual variability in production of cysteine cathepsins, powerful proteases that are the most potent mammalian collagenases and elastases and are upregulated during tissue-destructive disease progression. During this seminar, Dr. Platt will discuss 1) experimental and computational tools he has developed to better quantify and model the proteolytic network's role in disease progression, 2) fundamental insights and consequences of proteolytic network perturbation on extracellular matrix remodeling, and 3) applications for personalized medicine strategies to address patient variability in cardiovascular disease, and in cancer invasion and progression.