BioE Seminar Series
Thursday, October 27, 2016
4:30 pm - 5:30 pm
Fitzpatrick Center Schiciano Auditorium Side B
Zev Gartner, Ph.D.Associate Professor, Department of Pharmaceutical ChemistryUniversity of California, San FranciscoTitle: Building Tissues to Understand How Tissues Build ThemselvesThe human body contains over 10 trillion cells spanning hundreds of morphologically distinct cell types. These cells must work together for our bodies to function correctly. However, it remains a mystery how such an enormous diversity of cells coordinate their behaviors. Tissue structure - or the composition and physical arrangement of cells, extracellular matrix, and diffusible molecules - helps to coordinate cellular behaviors by organizing the flow of chemical, mechanical, and electrical information between cells. Thus, building tissue structure correctly and maintaining tissue structure over time are prerequisites for engineering functional organs and stopping the progression of diseases like cancer. I will share recent work in the lab focused on understanding how glandular tissues like the mammary and prostate glands self-organize robustly, as well as progress towards programming the autonomous folding of tissues using a strategy we call "tissue origami."