BioE Seminar Series
Thursday, November 10, 2016
4:30 pm - 5:30 pm
Fitzpatrick Center Schiciano Auditorium Side B
Kris Wood, Ph.D.Assistant ProfessorPharmacology and Cancer BiologyBiomedical EngineeringDuke UniverisityTitle: Systems-Level Approaches to Study and Manipulate Anticancer Drug ResistanceAbstract: Our laboratory uses genomic, pharmacological, and biochemical approaches to define the pathways of resistance to targeted anticancer therapies. For example, we recently developed a technique in which engineered lentiviral cDNAs encoding activators of major oncogenic signaling pathways are introduced into cells and then profiled to identify those capable of conferring resistance to drugs. In parallel, we have also developed analogous loss-of-function screening approaches based on CRISPR/Cas9 gene editing, and have used these approaches to map the pathways supporting intrinsic resistance to targeted therapies. In this talk, I will describe our large-scale application of these methods, as well as how the results of these studies have highlighted examples of "convergent" therapeutic resistance. Further, I will describe our discovery of new, selective, and potent combination therapies, several of which are now being explored clinically.