Bme Seminar: Extracellular Matrix, Growth Factors, Stem Cells, And The Immune System - Understanding And Recreating The Multifaceted Regenerative Microenvironment
Thursday, February 12, 2015
11:45 am - 1:00 pm
Mikael Martino, PhD
Regenerative medicine will play a crucial role in meeting future healthcare challenges, but its promises are largely not fulfilled today. For example, numerous clinical trials have failed to show effectiveness of therapies based on growth factors or stem/progenitor cells. Clearly, to improve therapies, we must better understand the interactions between the multiple actors that shape the regenerative microenvironment. First, I will present novel growth factor-based strategies inspired from the growth factor regulatory function of the extracellular matrix1-3. Secondly, I will focus on the immune modulation of stem cells and tissue regeneration, since understanding and controlling this aspect is certainly fundamental for the development of better regenerative medicine therapies. As an example, I will present recent findings demonstrating that the innate immune response controls tissue-resident and transplanted mesenchymal stem cell functions. Then, I will give perspectives for designing novel regenerative medicine therapies that integrate a control of the immune system.