BME Seminar - Elizabeth Hillman
Monday, May 18, 2015
10:00 am - 11:00 am
In-vivo brain imaging: building microscopes and using them In-vivo optical imaging techniques have become increasingly important for biomedical and neuroscience research. The massive recent growth in tools for genetically targeted sensors of cellular structure and function make optical techniques particularly well suited for answering questions related to physiology and disease processes in animal models. The two main research areas in my lab focus on the development of novel in-vivo optical imaging and photomodulation techniques, and then the use of these tools to understand the mechanisms underlying the regulation of blood flow in the brain. Our recent development of SCAPE microscopy, capable of imaging in 3D at very high speeds, has extended our studies into imaging apical dendrites in the awake behaving mouse brain, as well as in-toto imaging of freely crawling Drosophila larvae, the adult Drosophila brain and zebrafish models. Our imaging techniques focus on overcoming light scattering while capturing parallel information via fluorescence and absorption spectroscopy at high spatiotemporal resolution.