BioE Seminar: In vivo visualization and control of information flow through GTPase signaling networks
Thursday, March 19, 2015
4:30 pm - 5:30 pm
Fitzpatrick Center Schiciano Auditorium Side B
Klaus Hahn, PhD Professor of Pharmacology, UNC-Chapel Hill
Cell motility requires the orchestration of multiple dynamic cellular systems. To understand the organization of signaling interactions in time and space, we are developing tools to visualize and manipulate protein activity with seconds and micron resolution in living cells and animals. Our hope is that these will be easy to apply and therefore broadly applicable. This talk will describe new biosensors and biosensor designs to quantify information flow through Rho family GTPase networks, and modular design of domains that can be inserted in GEFs, GTPases and kinases to confer control by light or small molecules. Applications in motility and immune cell function will be described.