BioE Seminar: "Environmentally Responsive Polymers for Drug Targeting and Controlled Release"
Thursday, October 2, 2014
4:30 pm - 5:30 pm
Fitzpatrick Center Schiciano Auditorium Side A
Craig L. Duvall, Assistant Professor of Biomedical Engineering, Vanderbilt University. The Duvall Advanced Therapeutics Lab specializes in innovative design of smart polymer-based technologies for: (1) intracellular delivery of biological drugs such as peptides and nucleic acids, (2) proximity-activated targeting of drugs to sites of inflammation and matrix remodeling, and (3) long-term, "on-demand" drug release from localized depots. These delivery systems are designed to improve the therapeutic index of existing drugs and/or to serve as enabling technologies for manipulation of intracellular targets currently considered to be "undruggable." To achieve optimal, finely-tuned properties for these varied biomedical applications, polymers are utilized that respond to one or more environmental stimuli including pH, matrix metalloproteinases, reactive oxygen species, and temperature. This talk will focus primarily on cardiovascular drug delivery projects aimed at increasing longevity of autologous vascular bypass transplants, promoting vascularization of tissue engineering scaffolds, and improving limb survival and recovery following ischemic injury.